Implicor Contraindications




The information highlighted (if any) are the most recent updates for this brand.
Full Prescribing Info
Hypersensitivity to the active substances or to any of the excipients or to other beta-blockers (cross sensitivity between beta blockers may occur).
Symptomatic bradycardia.
Cardiogenic shock.
Sick sinus syndrome (including Sino-atrial block).
AV-block of 2nd and 3rd degree.
Acute myocardial infarction or patients with suspected acute myocardial infarction complicated by significant bradycardia, first degree heart block, systolic hypotension (less than 100 mmHg) and/or severe heart failure.
Severe (<90/50 mmHg) or symptomatic hypotension.
Unstable or acute heart failure.
Patients undergoing intermittent inotropic therapy with beta-receptor agonist.
Pacemaker dependent (heart rate imposed exclusively by the pacemaker).
Unstable angina.
Severe peripheral vascular disease.
Untreated pheochromocytoma.
Severe hepatic insufficiency.
Metabolic acidosis.
Combination with strong cytochrome P450 3A4 inhibitors such as azole antifungals (ketoconazole, itraconazole), macrolide antibiotics (clarithromycin, erythromycin per os, josamycin, telithromycin), HIV protease inhibitors (nelfinavir, ritonavir) and nefazodone.
Combination with verapamil or diltiazem which are moderate CYP3A4 inhibitors with heart rate reducing properties.
Pregnancy, lactation and women of child-bearing potential not using appropriate contraceptive measures.
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