Implicor

Implicor Dosage/Direction for Use

Manufacturer:

Servier

Distributor:

Zuellig
The information highlighted (if any) are the most recent updates for this brand.
Full Prescribing Info
Dosage/Direction for Use
The recommended dose of Metoprolol tartrate + Ivabradine (Implicor) is one tablet twice daily, once in the morning and once in the evening.
This medicine should only be used in patients controlled on stable doses of the monocomponents given concurrently when metoprolol is at the optimal dose.
It is recommended that the decision to titrate treatment takes place with the availability of serial heart measurements, ECG or ambulatory 24-hour monitoring and titration should be done with the individual components metoprolol and ivabradine, ensuring the patient is maintained at an optimal dose of metoprolol and ivabradine. If during treatment, heart rate decreases below 50 beats per minute at rest or the patient experiences symptoms related to bradycardia such as dizziness, fatigue or hypotension, down titration should be done with the individual monocomponents metoprolol and ivabradine, ensuring the patient is maintained at an optimal dose of metoprolol. After dose reduction, heart rate should be monitored.
Treatment must be discontinued if heart rate remains below 50 bpm or symptoms of bradycardia persist despite dose reduction.
Patients with renal impairment: No dosage adjustment is required in patients with renal insufficiency and creatinine clearance above 15 mL/min.
This medicine should be used with precaution in patients with creatinine clearance below 15 mL/min.
Patients with hepatic impairment: Metoprolol tartrate + Ivabradine (Implicor) can be administered in patients with mild hepatic impairment.
Caution should be exercised when administering in patients with moderate hepatic impairment.
This medicine is contraindicated in patients with severe hepatic impairment.
Older people: Metoprolol tartrate + Ivabradine (Implicor) can be administered in elderly patients with caution.
Pediatric population: The safety and efficacy of this medicine in children and adolescents have not been established. No data are available.
Method of administration: Metoprolol tartrate + Ivabradine (Implicor) should be taken orally twice daily during meals. The exposure of metoprolol is increased when administered with food. This should be considered in patients who currently take metoprolol in a fasting state and switch to Metoprolol tartrate + Ivabradine (Implicor).
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