Implicor

Implicor Use In Pregnancy & Lactation

Manufacturer:

Servier

Distributor:

Zuellig
The information highlighted (if any) are the most recent updates for this brand.
Full Prescribing Info
Use In Pregnancy & Lactation
Women of childbearing potential: Women of child-bearing potential should use appropriate contraceptive measures during treatment.
Use in Pregnancy: Based on existing data with the monocomponents, the use of Metoprolol tartrate + Ivabradine (Implicor) is contraindicated during pregnancy.
There are no or limited amount of data from the use of ivabradine in pregnant women.
Animal studies with ivabradine have shown reproductive toxicity. These studies have shown embryotoxic and teratogenic effects. The potential risk for humans is unknown. Therefore, ivabradine is contra-indicated during pregnancy.
There are no or limited amount of data (less than 300 pregnancy outcomes) from the use of metoprolol in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity with metoprolol. Metoprolol should only be administered during pregnancy where absolutely necessary. Beta blockers reduce placental perfusion, which may result in intrauterine fetal death, miscarriage or premature delivery. In addition, fetuses and newborns may be affected by adverse effects such as hypoglycemia, bradycardia, hypotension and breathing difficulties. The risk of cardiac and pulmonary complications is higher during the post-natal period. In the event of treatment during pregnancy, close fetal monitoring must be carried out, and continue for a few days after delivery.
Use in Lactation: Metoprolol tartrate + Ivabradine (Implicor) is contraindicated during breastfeeding.
Animal studies indicate that ivabradine is excreted in milk. Women that need treatment with ivabradine should stop breastfeeding and choose for another way of feeding their child. Metoprolol is concentrated in breast milk in a quantity that corresponds to three times the amount found in the mother's plasma.
Fertility: There are no clinical data on fertility with the use of Metoprolol tartrate + Ivabradine (Implicor).
Studies in rats with ivabradine and metoprolol have shown no effect on fertility in males and females.
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