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Indications and Dosage
Subcutaneous
Diabetes mellitus Adult: According to requirements; administer once daily at the same time each day. For insulin-naive patients: May initiate with 10 IU once daily. Adjust subsequently based on response to achieve glycaemic targets. Usual range: 2-100 IU/day.
Child: ≥6 yr: According to requirements; administer once daily at the same time each day. |
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Renal Impairment
Decreased dose may be necessary.
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Hepatic Impairment
Decreased dose may be necessary.
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Contraindications
Hypoglycaemia; IV route.
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Special Precautions
Renal or hepatic impairment; pregnancy; lactation; child <6 yrs. Transferring from other insulin. Monitor serum glucose, potassium, electrolytes, HbA1c and lipid profile. Concomitant illness esp infections; hypokalaemia.
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Adverse Reactions
Hypoglycaemia; oedema; pruritus; rash; hypersensitivity reactions; lipoatrophy or lipohypertrophy with SC Inj (rotate Inj site).
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Drug Interactions
Effects may be increased by: oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog (e.g. octreotide), sulfonamide antibiotics. Effects may be decreased by: corticosteroids, niacin, danazol, diuretics, sympathomimetic agents, isoniazid, phenothiazine derivatives, somatropin, thyroid hormones, oral contraceptives, lithium. Signs of hypoglycaemia may be masked by β-blockers, clonidine.
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Action
Description: Insulin glargine, a long-acting analog of human insulin, regulates carbohydrate, protein and fat metabolism by inhibiting hepatic glucose production and lipolysis, and enhancing peripheral glucose disposal.
Onset: 1 hr Duration: 24 hrs. |
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MIMS Class
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