Invega

Invega

paliperidone

Manufacturer:

Johnson & Johnson

Distributor:

Zuellig
Concise Prescribing Info
Contents
Paliperidone.
Indications/Uses
Recurrence prevention & maintenance therapy for schizophrenia. For treatment of acute manic episodes associated w/ bipolar I disorder.
Dosage/Direction for Use
Adult ≥18 yr Schizophrenia 6 mg once daily in the morning. Dose range: 3-12 mg once daily. May be increased in increments of 3 mg/day at intervals of >5 days. Bipolar disorder 9 mg once daily in the morning. Dose range: 3-12 mg once daily. May be increased in increments of 12 mg/day at intervals of ≥2 days. Patient w/ mild renal impairment (CrCl 50-80 mL/min) Initially 3 mg once daily up to 6 mg once daily; moderate to severe renal impairment (CrCl 10-50 mL/min) 3 mg once daily.
Administration
May be taken with or without food: Take consistently either always w/ or w/o food. Swallow whole, do not divide/chew/crush.
Contraindications
Pregnancy (last trimester) & lactation.
Special Precautions
Parkinson's disease or dementia, neuroleptic malignant syndrome, tardive dyskinesia, history of cardiac arrhythmias & congenital long QT syndrome; diabetic patients or in patients at risk of diabetes; known CV disease, cerebrovascular disease or conditions that predispose to hypotension (eg dehydration, hypovolemia); history of seizures; preexisting severe GI narrowing or w/ dysphagia. May impair ability to drive or operate machinery. Pregnancy. Elderly.
Adverse Reactions
Parkinsonism, headache, dizziness, somnolence, extrapyramidal disorder, akathisia, tremor, hypertonia, dystonia & sedation. Cardiac disorders, orthostatic hypotension. GI disorders eg vomiting, dry mouth, abdominal pain & salivary hypersecretion. Asthenia & fatigue. Increased appetite, agitation.
Drug Interactions
Drugs metabolized by cytochrome P-450. Centrally acting drugs, alcohol, l-dopa, other dopamine agonists, carbamazepine & risperidone.
MIMS Class
ATC Classification
N05AX13 - paliperidone ; Belongs to the class of other antipsychotics.
Presentation/Packing
Form
Invega extentab 3 mg
Packing/Price
28's (P7,350/pack)
Form
Invega extentab 6 mg
Packing/Price
28's (P7,350/pack)
Form
Invega extentab 9 mg
Packing/Price
28's (P12,495/pack)
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