Each tablet contains: Irbesartan 150 mg and Hydrochlorothiazide 12.5 mg.
Irbesartan is a specific competitive antagonist of Angiotensin-II receptor (AT1 subtype). The parent drug is orally active and does not require biotransformation.
Hydrochlorothiazide is a moderately potent diuretic for treating hypotension. Its main action is the inhibition of the NaCl reabsorption in the distal convoluted tubules of the kidney.