Irbezyd-H

Irbezyd-H

irbesartan + hydrochlorothiazide

Manufacturer:

Cadila Healthcare

Distributor:

Metro Drug

Marketer:

Zydus Healthcare Phils
Concise Prescribing Info
Contents
Per 150 mg/12.5 mg tab Irbesartan 150 mg, hydrochlorothiazide 12.5 mg. Per 300 mg/12.5 mg tab Irbesartan 300 mg, hydrochlorothiazide 12.5 mg.
Dosage/Direction for Use
Patient whose BP is not adequately controlled w/ hydrochlorothiazide or irbesartan 150 mg alone 150 mg/12.5 mg once daily. Patient insufficiently controlled by irbesartan 300 mg or Irbezyd-H 150 mg/12.5 mg 300 mg/12.5 mg once daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to irbesartan, hydrochlorothiazide & other sulfonamide-derived drugs. Anuria.
Special Precautions
Risk of symptomatic hypotension. Pregnancy & lactation. Childn & adolescents. Elderly. Hydrochlorothiazide: Monitor electrolyte imbalance (eg, hyponatremia, hypochloremic alkalosis & hypokalemia); hyperglycemia, hyperuricemia, hypomagnesemia. Discontinue before carrying out tests for parathyroid function. Renal & hepatic impairment.
Adverse Reactions
Headache, sinus abnormality, cough, upper resp infection, pharyngitis, diarrhea, rhinitis, UTI, rash, anxiety/nervousness & muscle cramp.
Drug Interactions
Hydrochlorothiazide: Possible potentiation of orthostatic hypotension w/ alcohol, barbiturates or narcotics. Oral antidiabetic agents & insulin. Additive effect or potentiation w/ other antihypertensives. Decreased absorption w/ cholestyramine & colestipol resins. Intensified electrolyte depletion particularly hypokalemia w/ corticosteroids, ACTH. Possible decreased response to pressor amines (eg, norepinephrine). Potential increased responsiveness to nondepolarizing skeletal muscle relaxants eg, tubocurarine. Lithium. Reduced effect by NSAIDs.
ATC Classification
C09DA04 - irbesartan and diuretics ; Belongs to the class of angiotensin II receptor blockers (ARBs) in combination with diuretics. Used in the treatment of cardiovascular disease.
Presentation/Packing
Form
Irbezyd-H 150 mg/12.5 mg tab
Packing/Price
30's (P19.64/tab, P589.29/box)
Form
Irbezyd-H 300 mg/12.5 mg tab
Packing/Price
30's (P29.46/tab, P883.93/box)
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