Irbezyd-H Description

irbesartan + hydrochlorothiazide


Cadila Healthcare


Metro Drug


Zydus Healthcare Phils
Full Prescribing Info
Each tablet contains: Irbezyd H 150/12.5: Irbesartan 150 mg and Hydrochlorothiazide 12.5mg
Irbezyd H 300/12.5: Irbesartan 300 mg and Hydrochlorothiazide 12.5mg
Irbesartan+hydrochlorothiazide Tablet is a combination of an angiotensin II receptor antagonist (AT1 subtype), Irbesartan, and a thiazide diuretic, hydrochlorothiazide (HCTZ).
Irbesartan is a non-peptide compound, chemically described as a 2-butyl-3-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]-1,3-diazaspiro[4.4]non-1-en-4-one.
Irbesartan is a white to off-white crystalline powder with a molecular weight of 428.5. It is a nonpolar compound with a partition coefficient (octanol/water) of 10.1 at pH of 7.4. Irbesartan is slightly soluble in alcohol and methylene chloride and practically insoluble in water.
Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H8ClN3O4S2.
Hydrochlorothiazide is a white, or practically white crystalline powder with a molecular weight of 297.7. Hydrochlorothiazide is slightly soluble in water, freely soluble in sodium hydroxide solution, in n-butylamine and in diethyl formamide, sparingly soluble in methanol, insoluble in ether, in chloroform and in diluent mineral acid.
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