Ileus and respiratory distress syndrome has been found to be more common in the offspring of pregnant women who received isoxsuprine. Incidence of respiratory distress syndrome increases as the isoxsuprine concentration in cord blood exceeds 10 ng/mL. The incidence of hypocalcemia and hypotension rises progressively with increasing isoxsuprine concentration in the cord blood.
Use isoxsuprine in pregnant women only when the potential benefit outweighs the potential risk to mother and infant.
There are no reports of problems with isoxsuprine in breastfeeding babies.