Not for use in patients w/ type 1 diabetes. Patients at risk of ketoacidosis while on treatment include patients on a very low carbohydrate diet, w/ an acute illness, pancreatic disorders suggesting insulin deficiency (eg, type 1 diabetes, history of pancreatitis or pancreatic surgery), insulin dose reduction (including insulin pump failure), alcohol abuse, severe dehydration, w/ history of ketoacidosis. Discontinue if ketoacidosis is suspected. Discontinue & institute prompt treatment in case of necrotizing fasciitis of the perineum (Fournier's gangrene). Patients for whom an empagliflozin-induced drop in BP could pose a risk eg, w/ known CV disease & on antihypertensive therapy w/ history of hypotension or patients ≥75 yr. Monitor vol status & electrolytes in case of conditions that may lead to fluid loss (eg, GI illness). Interrupt treatment temporarily in patients w/ complicated UTI. Rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.Not recommended for patients w/ renal impairment (eGFR <30 mL/min/1.73 m2
). Pregnancy & lactation. Childn <18 yr. Elderly ≥85 yr.