Jardiance

Jardiance

empagliflozin

Manufacturer:

Boehringer Ingelheim

Distributor:

Metro Drug
Concise Prescribing Info
Contents
Empagliflozin
Indications/Uses
As monotherapy or in combination w/ other glucose-lowering drugs including insulin in the treatment of type 2 DM when diet & exercise alone do not provide adequate glycemic control. Patients w/ type 2 DM & established CV disease to reduce the risk of CV death; should be used in conjunction w/ other measures to reduce CV risk in line w/ the current standard of care.
Dosage/Direction for Use
Initially 10 mg once daily, may be increased to 25 mg once daily in patients requiring additional glycemic control. Lower dose when combined w/ sulphonylurea or insulin to reduce risk of hypoglycemia.
Administration
May be taken with or without food: Swallow whole w/ water.
Contraindications
Hypersensitivity. Patients w/ CKD stage 4 or 5 (severely impaired renal function including patients receiving dialysis; eGFR <30 mL/min/1.73 m2 or CrCl <30 mL/min) or eGFR persistently <45 mL/min/1.73 m2 or CrCl persistently <45 mL/min (CKD Stage 3B). Rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.
Special Precautions
Not for use in patients w/ type 1 diabetes. Patients at risk of ketoacidosis while on treatment include patients on a very low carbohydrate diet, w/ an acute illness, pancreatic disorders suggesting insulin deficiency (eg, type 1 diabetes, history of pancreatitis or pancreatic surgery), insulin dose reduction (including insulin pump failure), alcohol abuse, severe dehydration, w/ history of ketoacidosis. Discontinue use if eGFR is persistently <45 mL/min/1.73 m2 or CrCl <45 mL/min. Assess renal function prior to the initiation of treatment & periodically during treatment. Patients w/ known CV disease & on antihypertensive therapy w/ history of hypotension or patients ≥75 yr. Interrupt treatment temporarily w/ complicated UTI or until fluid loss is corrected & monitor vol status & electrolytes. Pregnancy & lactation. Childn <18 yr. Elderly ≥85 yr.
Adverse Reactions
Vag moniliasis, vulvovaginitis, balanitis & other genital infections, UTI (including pyelonephritis & urosepsis); hypoglycaemia, ketoacidosis; pruritus, allergic skin reactions (eg, rash, urticaria), angioedema; vol depletion; increased urination, dysuria; thirst; decreased GFR; increased blood creatinine, hematocrit & serum lipids.
Drug Interactions
May add to the diuretic effect of thiazide & loop diuretics & may increase risk of dehydration & hypotension. May increase risk of hypoglycemia w/ insulin & insulin secretagogues eg, sulphonylureas.
MIMS Class
ATC Classification
A10BK03 - empagliflozin ; Belongs to the class of sodium-glucose co-transporter 2 (SGLT2) inhibitors. Used in the treatment of diabetes.
Presentation/Packing
Form
Jardiance FC tab 25 mg
Packing/Price
30's (P1,500/box)
Form
Jardiance FC tab 10 mg
Packing/Price
30's (P1,448.4/box)
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