Not for use in patients w/ type 1 diabetes. Patients at risk of ketoacidosis while on treatment include patients on a very low carbohydrate diet, w/ an acute illness, pancreatic disorders suggesting insulin deficiency (eg, type 1 diabetes, history of pancreatitis or pancreatic surgery), insulin dose reduction (including insulin pump failure), alcohol abuse, severe dehydration, w/ history of ketoacidosis. Discontinue use if eGFR is persistently <45 mL/min/1.73 m2
or CrCl <45 mL/min. Assess renal function prior to the initiation of treatment & periodically during treatment. Patients w/ known CV disease & on antihypertensive therapy w/ history of hypotension or patients ≥75 yr. Interrupt treatment temporarily w/ complicated UTI or until fluid loss is corrected & monitor vol status & electrolytes. Pregnancy & lactation. Childn <18 yr. Elderly ≥85 yr.