Jovia

Jovia

escitalopram

Manufacturer:

Medichem

Distributor:

United Lab
Concise Prescribing Info
Contents
Escitalopram oxalate
Indications/Uses
Major depressive disorder, social & generalized anxiety disorder, obsessive-compulsive disorder, panic disorder w/ or w/o agoraphobia.
Dosage/Direction for Use
Major depressive disorder 10 mg once daily for at least 6 mth to consolidate response & prevent relapse. Max: 20 mg/day. Social & generalized anxiety disorder, obsessive-compulsive disorder 10 mg once daily. Max: 20 mg/day Panic disorder w/ or w/o agoraphobia Initially 5 mg once daily for 1st wk before increasing to 10 mg for ≥3 mth. Max: 20 mg/day. Elderly >65 yr, hepatic impairment & poor CYP2C19 metabolizers Initially 5 mg/day. Max: 10 mg/day.
Administration
May be taken with or without food: Take in the morning or evening.
Contraindications
Hypersensitivity to citalopram or escitalopram. Concomitant use w/ pimozide & MAOIs. When patient enters a manic phase.
Special Precautions
Monitor for clinical worsening, suicidality or unusual changes in behavior; serotonin syndrome or neuroleptic malignant syndrome (NMS)-like reactions. Screening for bipolar disorder. Gradually taper dose over a period of several wk or mth to avoid discontinuation symptoms. History or predisposing conditions to abnormal bleeding & those receiving oral anticoagulants, atypical antipsychotics, phenothiazines, TCAs, acetylsalicylic acid, NSAIDs, ticlopidine & dipyridamole. Cirrhotic patients & those treated w/ drugs known to cause hyponatremia. Activation of mania/hypomania. Diabetes; diseases/conditions that produce altered metabolism or hemodynamic responses. May affect ability to drive or operate machinery. Pregnancy & lactation. Childn & adolescents. Elderly.
Adverse Reactions
Flu-like symptoms, fatigue, allergic reaction, anaphylaxis, limb pain, toothache, fever, edema of extremities, chills, asthenia, malaise, fall, cervical lymphadenopathy; palpitation, HTN, postural hypotension, bradycardia, tachycardia, abnormal ECG, ECG Qt prolongation, flushing, hot flushes, chest pain, syncope, atrial fibrillation, cardiac failure, MI, torsade de pointes, ventricular arrhythmia/tachycardia, varicose vein, DVT, thrombosis, phlebitis; dizziness, vertigo, insomnia, somnolence, headache, migraine, paresthesia, yawning, light-headed feeling, tremor, restless legs, shaking, twitching, dysequilibrium, tics, carpal tunnel syndrome, involuntary muscle contractions, sluggishness, abnormal coordination, faintness, hyperreflexia, increased muscular tone, extrapyramidal disorders, movement disorder, lethargy, irritability, impaired concentration, jitteriness, panic reaction, agitation, apathy, forgetfulness, amnesia, depression, aggravated depression, nervousness, tremulousness nervous, aggravated restlessness, anxiety attack, bruxism, confusion, depersonalization, disorientation, emotional lability, feeling unreal, abnormal crying, excitability, auditory hallucination, visual hallucination, suicidal tendency, suicide attempt, serotonin syndrome, dyskinesia, tardive dyskinesia, convulsions, seizures, akathisia, dysarthria, dystonia, hypoesthesia, myoclonus, nystagmus, abnormal gait, acute psychosis, aggression, anger, delirium, delusion, nightmare, abnormal dreaming, paranoia; dry mouth, nausea, diarrhea, constipation, indigestion, abdominal pain, vomiting, flatulence, heartburn, abdominal cramps, gastroenteritis, GERD, bloating, abdominal discomfort, dyspepsia, increased stool frequency, belching, gastritis, hemorrhoids, gagging, gastric polyposis, difficult swallowing, GI hemorrhage, pancreatitis, rectal hemorrhage; bruise, anemia, nosebleed, hematoma, hemolytic anemia, leukopenia, thrombocytopenia, increased INR, decreased prothrombin; increased/decreased wt, increased/decreased appetite, carbohydrate craving, hyperglycemia, hypoglycemia, thirst, increased bilirubin, gout, hypercholesterolemia, hyperprolactinemia, hypokalemia, inappropriate ADH secretion, syndrome of inappropriate antidiuretic hormone, ejaculation disorder, impotence, priapism, decreased libido, anorgasmia; neck/shoulder pain, leg pain, arthralgia, myalgia, jaw stiffness, muscle cramps/stiffness, arthritis, muscle weakness, back discomfort, arthropathy, jaw pain, joint stiffness, rhabdomyolysis; rhinitis, sinusitis, bronchitis, sinus congestion, coughing, nasal congestion, sinus headache, asthma, shortness of breath, laryngitis, pneumonia, tracheitis, epistaxis, tightness of chest, pulmonary embolism; abnormal liver function, hepatitis, fulminant hepatitis, hepatic failure, hepatic necrosis, increased hepatic enzymes; increased sweating, rash, pruritus, acne, alopecia, eczema, dermatitis, dry skin, folliculitis, lipoma, furunculosis, dry lips, skin nodule, ecchymosis, angioedema, urticaria, erythema multiforme, photosensitivity reaction, Stevens-Johnson syndrome, toxic epidermal necrolysis; blurred vision, conjunctivitis, abnormal vision, dry eyes, eye irritation, visual disturbance, eye infection, mydriasis, diplopia, glaucoma, choreoathetosis, earache, tinnitus, taste alteration, taste disturbance, metallic taste; menstrual disorder/cramps, menorrhagia, metrorrhagia, breast neoplasm, pelvic inflammation, premenstrual syndrome, spotting between menses, urinary frequency, UTI, urinary urgency, kidney stone, dysuria, blood in urine, galactorrhea, acute renal failure; spontaneous abortion.
Drug Interactions
Racemic citalopram, other SSRIs, SNRIs, tryptophan, MAOIs, alcohol & other CNS drugs. Potentially life-threatening serotonin syndrome w/ serotonergic drugs (eg, triptans, sumatriptan, linezolid, lithium, tramadol or St. John's wort). May potentiate risk of upper GI bleeding w/ NSAIDs, aspirin, warfarin, clopidogrel, ticlopidine & dipyridamole. Seizure threshold lowering w/ TCAs, phenothiazines, thioxanthines, butyrophenones, mefloquine, bupropion & tramadol. May increase Cmax & AUC of drugs metabolized by CYP2D6 [eg antidepressants (desipramine, clomipramine, nortriptyline), antipsychotics (risperidone, thioridazine, haloperidol), flecainide, propafenone & metoprolol]; decrease Cmax & AUC of ketoconazole. Increased clearance w/ carbamazepine. Increased plasma conc w/ CYP2C19 inhibitors eg omeprazole, esomeprazole, fluoxetine, fluvoxamine, lansoprazole & ticlopidine. Increased AUC & Cmax w/ cimetidine. CYP3A4 inhibitors, theophylline, digoxin.
MIMS Class
Antidepressants
ATC Classification
N06AB10 - escitalopram ; Belongs to the class of selective serotonin reuptake inhibitors. Used in the management of depression.
Presentation/Packing
Form
Jovia FC tab 10 mg
Packing/Price
28's (P56.5/tab)
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