Kary Uni

Kary Uni

pirenoxine sodium




Metro Drug
Full Prescribing Info
Pirenoxine (Kary Uni) 50 mcg/mL ophthalmic suspension is an orange, sterile, aqeous ophthalmic suspension containing 50 mcg of pirenoxine as an active ingredient in each mL.
Excipients/Inactive Ingredients: It also contains disodium edetate hydrate, benzalkonium chloride, concentrated glycerin and polyoxyethylene hydrogenated castor oil 60 as additives.
According to the quinoid theory, senile cataract is a manifestation of the degeneration of lens protein induced by quinone which are formed owing to disorder of tryptophan metabolism. Since pirexonine has a higher affinity for water soluble lens protein than quinones, it competitivelt inhibits quinone binding and thereby prevents protein degeneration.
Pirenoxine (Kary Uni) 50 mcg/mL ophthalmic suspension is ready to use, eliminating the reconstitution procedure required for the conventional products.
Its pH is between 3.4 and 4.0 and the osmolar ratio is between 0.9 and 1.2. Immediately after topical application, the pH of this preparation becomes equivalent to that of the lacrimal fluid, the suspended pirenoxine particles being dissolved in the lacrimal fluid.
Incipient senile cataract.
Dosage/Direction for Use
Shake well before use, and instill 1 or 2 drops a time, 3 to 5 times daily.
Special Precautions
At the time of administration: Do not touch the tip of the bottle to the eye directly in order to avoid the contamination of the drug.
Since particles in the suspension may not disperse depending on storage conditions even after well shaking, store the product in an upright position.
This product is discolored after contamination with metal ions.
Adverse Reactions
Rarely: <0.1%, infrequently: 0.1%-<5%, no specific designation: ≥5% or frequency unknown.
Blepharitis, contact dermatitis, and other symptoms of hypersensitivity may occur. When such symptoms occur, discontinue the use.
Diffuse superficial keratitis, conjunctival injection, irritation, itching, etc. may occur. When such symptoms occur, discontinue the use.
Store at temperatures not exceeding 30°C.
ATC Classification
S01XA - Other ophthalmologicals ; Used in ophthalmic preparations.
Ophthalmic susp 50 mcg/mL (0.005% w/v) x 5 mL.
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