CT Lab Farmaceutico


Concise Prescribing Info
Cefuroxime Na
Resp tract infections (acute & chronic bronchitis, infected bronchiectasis, bacterial pneumonia, lung abscess & post-op chest infections), ENT infections (sinusitis, tonsilitis & pharyngitis), UTI (acute & chronic pyelonephritis, cystitis & asymptomatic bacteriuria), soft tissue infections (cellulitis, erysipelas, peritonitis & wound infections), bone & joint infections (osteomyelitis & septic arthritis), O & G infections (pelvic inflammatory diseases), gonorrhea, other infections including septicemia & meningitis. Prophylaxis against infection in abdominal, pelvic, orthopedic, cardiac pulmonary, esophageal & vascular surgery.
Dosage/Direction for Use
Adult 750 mg IM or IV tid. Total daily dose: 3-6 g. More severe infections 1.5 g IV tid. Childn & infant 30-100 mg/kg/day in 3 or 4 divided doses. Neonate 30-100 mg/kg/day in 2-3 divided doses. Gonorrhea 1.5 g single dose or 750 mg in 2 divided doses. Meningitis Adult 3 g IV every 8 hr. Childn & infant 150-250 mg/kg/day IV in 3 or 4 divided doses. Neonate 100 mg/kg/day IV. Prophylaxis for abdominal, pelvic & orthopedic operations 1.5 g IV w/ anesth induction. May be supplemented w/ two 750 mg IM doses 8 & 16 hr later. Cardiac, pulmonary, esophageal & vascular operations 1.5 g IV w/ induction of anesth continuing w/ 750 mg IM tid for further 24-48 hr. Total joint replacement 1.5 g cefuroxime powd mixed dry w/ methyl methacrylate cement polymer before adding liqd monomer. Renal impairment (CrCl 10-20 mL/min) 750 mg bid, severe impairment (CrCl <10 mL/min) 750 mg once daily. Patient on hemodialysis 750 mg at the end of each dialysis.
Hypersensitivity to cephalosporins. Acute porphyria.
Special Precautions
Patient w/ penicillin allergy. Pronounced renal insufficiency. Increased renal toxicity in concomitant w/ other nephrotoxic drug. Long-term use may develop nonsusceptible microorganisms. Patients receiving concurrent treatment w/ diuretics eg, furosemide & aminoglycosides. May interfere w/ some laboratory tests (false +ve result in Benedict's, Fehling & Clinitest, +ve Coombs' test). Pregnancy (1st trimester).
Adverse Reactions
Glossitis, nausea, vomiting, diarrhea, gastric pyrosis, abdominal pain. Very seldom, urticaria or cutaneous rash, pruritus & arthralgia. Rarely, pseumembranous colitis, erythema multiforme, Stevens-Johnson syndrome, anaphylaxis & toxic epidermal necrolysis. Eosinophilia, leukopenia, neutropenia, decreased Hb conc. Increased serum transaminase, total bilirubin & azotemia; vertigo, sensation of thoracic constriction, candida vaginitis, fever, headache, reversible interstitial nephritis, nervousness; sleep disturbances, confusion, hypertonia, serum sickness-like reactions, transient hepatitis & cholestatic jaundice; hemolytic anemia, inj site pain, thrombophlebitis.
Drug Interactions
Cross-allergy to penicillin. Increased plasma conc w/ probenecid. Additive effects in combination w/ aminoglycosides.
MIMS Class
ATC Classification
J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Kefox powd for inj 250 mg
1's (P220/vial)
Kefox powd for inj 750 mg
1's (P520/vial)
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