Each vial contains 100 mg of pembrolizumab in 4 mL of solution. Each 1 mL of solution contains 25 mg of pembrolizumab and is formulated in: L-histidine (1.55 mg), polysorbate 80 (0.2 mg), sucrose (70 mg), and Water for Injection, USP.
Chemistry: Pembrolizumab (KEYTRUDA) is a selective humanized monoclonal antibody designed to block the interaction between PD-1 and its ligands, PD-L1 and PD-L2. Pembrolizumab is an IgG4 kappa immunoglobulin with an approximate molecular weight of 149 kDa.
Composition: Active Ingredient: Pembrolizumab; L-histidine, L-histidine hydrochloride monohydrate, Sucrose, Polysorbate 80, Water for injection.