Klaricid/Klaricid OD

Klaricid/Klaricid OD

clarithromycin

Manufacturer:

Abbott

Distributor:

Abbott
Concise Prescribing Info
Contents
Clarithromycin
Indications/Uses
Lower & upper resp tract, skin & soft tissue infections. Tab: Odontogenic infections. Susp: Disseminated or localized Mycobacterium avium or Mycobacterium intracellulare. Localized infections due to Mycobacterium chelonae, Mycobacterium fortuitum or Mycobacterium kansaii. Acute otitis media.
Dosage/Direction for Use
Klaricid tab Adult & childn ≥12 yr 250 mg bid. Severe infections 500 mg bid. Duration of therapy: 5-14 days; CAP & sinusitis: 6-14 days. Mycobacterial infections, MAC prophylaxis 500 mg bid. Odontogenic infections 250 mg bid for 5 days. Peptic ulcer due to H. pylori infection Clarithromycin: 500 mg bid + proton pump inhibitor for 7-14 days. Renal impairment w/ CrCl <30 mL/min 250 mg once daily or 250 mg bid in more severe infections. Klaricid OD Adult & childn ≥12 yr 500 mg once daily. Severe infections 1,000 mg once daily. Duration: 5-14 day; CAP & sinusitis: 6-14 days. Odontogenic infections 500 mg once daily for 5 days. Severe renal impairment (CrCl <30 mL/min) 250 mg once daily or 500 mg once daily in more severe infections. Klaricid susp Childn <12 yr 7.5 mg/kg bid up to max of 500 mg bid for non-mycobacterial infections for 5-10 days. Mycobacterial infections 7.5-15 mg/kg bid, max: 500 mg bid.
Administration
May be taken with or without food. OD tab: Should be taken with food. Swallow whole, do not chew/crush. May be taken w/ milk.
Contraindications
Hypersensitivity to macrolides. Concomitant use w/ astemizole, cisapride, pimozide, terfenadine, ergot alkaloids, oral midazolam, HMG-CoA reductase inhibitors, colchicine, ticagrelor or ranolazine. Patients w/ history of QT prolongation or ventricular cardiac arrhythmia including torsades de pointes, hypokalemia. Hepatic failure in combination w/ renal impairment.
Special Precautions
Risk of non-susceptible bacteria & fungi w/ long-term use. Hepatic & moderate to severe renal impairment. Pseudomembranous colitis & C. difficile-associated diarrhea may occur. Prolongation of QT interval. Perform sensitivity testing in patients w/ pneumonia & skin & soft tissue infections. Discontinue use if signs & symptoms of hepatitis occurs. May affect ability to drive or operate machinery. Pregnancy & lactation. Tab: Galactose intolerance, Lapp lactase deficiency or glucose galactose malabsorption. Susp: Fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency.
Adverse Reactions
Abdominal pain, diarrhea, nausea, vomiting & taste perversion.
Drug Interactions
May result in QT prolongation & cardiac arrhythmias w/ cisapride, pimozide, astemizole & terfenadine. Acute ergot toxicity w/ ergotamine/dihydroergotamine. Increased AUC of oral midazolam, atazanavir. Increase plasma conc of HMG-CoA Reductase Inhibitors, omeprazole. Accelerates the metabolism & lowers the plasma conc w/ efavirenz, nevirapine, rifampicin, rifabutin & rifapentine. Decreased exposure w/ etravirine. Inhibition of metabolism w/ ritonavir. Risk of torsades de pointes w/ antiarrhythmics. Hypoglycemia w/ oral hypoglycemic agents/insulin. Elevations in drug conc w/ CYP3A-based drugs. Increased in phosphodiesterase inhibitor exposure w/ sildenafil, tadalafil & vardenafil. Increased theophylline & carbamazepine levels. Higher serum conc of tolterodine. Increased CNS effects w/ triazolobenzodiazepines. Increased exposure to colchicine, digoxin. Decreased steady-state conc of zidovudine. Risk of hypotension w/ Ca channel blockers. Prolonged effect w/ itraconazole. Increased AUC & Cmax of saquinavir. Phenytoin & valproate.
MIMS Class
ATC Classification
J01FA09 - clarithromycin ; Belongs to the class of macrolides. Used in the systemic treatment of infections.
Presentation/Packing
Form
Klaricid OD tab 500 mg
Packing/Price
30's (P5,578.17/pack);5's (P806.02/pack)
Form
Klaricid Pediatric oral susp 250 mg/5 mL
Packing/Price
25 mL x 1's;50 mL x 1's;70 mL x 1's
/philippines/image/info/klaricid pediatric oral susp 250 mg-5 ml/250 mg-5 ml x 50 ml?id=2db4bc75-5fa9-4694-8c5d-aafe00f27d96
/philippines/image/info/klaricid pediatric oral susp 250 mg-5 ml/250 mg-5 ml x 25 ml?id=66bfe3b8-54e3-4c44-88b7-aafe00f27d96
/philippines/image/info/klaricid pediatric oral susp 250 mg-5 ml/250 mg-5 ml x 70 ml?id=74bb152b-f59f-4108-b7b4-aafe00f27d96
Form
Klaricid tab 250 mg
Packing/Price
30's (P3,972.76/pack)
Form
Klaricid Pediatric oral susp 125 mg/5 mL
Packing/Price
25 mL x 1's;50 mL x 1's;70 mL x 1's
/philippines/image/info/klaricid pediatric oral susp 125 mg-5 ml/125 mg-5 ml x 25 ml?id=0f1f58e4-0a55-434e-be0f-aafe00f27d75
/philippines/image/info/klaricid pediatric oral susp 125 mg-5 ml/125 mg-5 ml x 50 ml?id=1d70efd6-bf0e-45c0-ba26-aafe00f27d75
/philippines/image/info/klaricid pediatric oral susp 125 mg-5 ml/125 mg-5 ml x 70 ml?id=696dfb63-3204-4c75-a355-aafe00f27d75
Form
Klaricid tab 500 mg
Packing/Price
30's (P7,280.91/pack)
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