Klaricid/Klaricid OD

Klaricid/Klaricid OD Dosage/Direction for Use

clarithromycin

Manufacturer:

Abbott

Distributor:

Abbott
Full Prescribing Info
Dosage/Direction for Use
Klaricid: Adults: The usual recommended dosage of clarithromycin in adults and children 12 years of age or older, is one 250 mg tablet twice daily. In more severe infections, the dosage can be increased to 500 mg twice daily. The usual duration of therapy is 5 to 14 days, excluding treatment of community acquired pneumonia and sinusitis which require 6 to 14 days of therapy.
Dosage in patients with mycobacterial infections: The recommended dose for adults with mycobacterial infections is 500 mg b.i.d.
Treatment of disseminated MAC infections in AIDS patients should be continued, as long as clinical and microbiological benefit is demonstrated. Clarithromycin should be used in conjunction with other antimycobacterial agents. Treatment of other nontuberculous mycobacterial infections should continue at the discretion of the physician.
Dosage for MAC prophylaxis: The recommended dosage of clarithromycin in adults is 500 mg twice daily.
In the treatment of odontogenic infections, the dosage of clarithromycin is one 250 mg tablet twice daily for five days.
In patients with peptic ulcer due to H. pylori infection, clarithromycin can be administered in a dose of 500mg twice daily in combination with other appropriate anti-microbial treatments and a proton pump inhibitor for 7-14 days in consultation with national or international guideline recommendations for H. pylori eradication.
Renal Impairment: In patients with renal impairment with creatinine clearance less than 30 ml/min, the dosage of clarithromycin should be reduced by one-half, i.e., 250 mg once daily, or 250 mg twice daily in more severe infections. Treatment should not be continued beyond 14 days in these patients.
Pediatric Population: The use of clarithromycin (Klaricid) has not been studied in children less than 12 years of age.
Klaricid OD: Adults: The usual recommended dosage of clarithromycin (Klaricid OD) tablets in adults and children 12 years of age or older is 500 mg once-daily with food. In more severe infections, the dosage may be increased to 1000 mg once-daily (2 x 500 mg). The usual duration of therapy is 5 to 14 days, excluding treatment of community acquired pneumonia and sinusitis which require 6 to 14 days therapy.
Odontogenic Infections: In the treatment of odontogenic infections, the usual dosage of clarithromycin (Klaricid OD) is one 500 mg tablet once daily for 5 days. Do not crush or chew clarithromycin modified release tablets.
Renal Impairment: In patients with severe renal impairment (creatinine clearance less than 30 mL/min), the usual recommended dose is 250 mg once daily. Because the modified-release tablet cannot be split, instead immediate-release tablets should be used. In more severe infections, the recommended dose is one 500 mg Clarithromycin modified-release tablet once daily. No dose adjustment is required for patients with moderate renal impairment (creatinine clearance 30 to 60 mL/min).
Pediatric population: The use of clarithromycin (Klaricid OD) has not been studied in children less than 12 years of age.
Klaricid Pediatric: Pediatric Patients under 12 years of age: Clinical trials have been conducted using clarithromycin pediatric suspension in children 6 months to 12 years of age. Therefore, children under 12 years of age should use clarithromycin pediatric suspension (granules for oral suspension).
The recommended daily dosage of Clarithromycin Pediatric Suspension (125 mg/5 mL or 250 mg/5 mL) in children is 7.5 mg/kg b.i.d. up to a maximum dose of 500 mg b.i.d. for non-mycobacterial infections. The usual duration of treatment is for 5 to 10 days depending on the pathogen involved and the severity of the condition. The prepared suspension can be taken with or without meals, and can be taken with milk.
The following table is a suggested guide for determining dosage, based on the weight of the child and the concentration of the suspension (125 mg/5 mL or 250 mg/5 mL). (See Table 3.)

Click on icon to see table/diagram/image

Dosage in Patients with Mycobacterial Infections: In children with disseminated or localized mycobacterial infections (M. avium, M. intracellulare, M. chelonae, M. fortuitum, M. kansasii), the recommended dose is 7.5 to 15 mg/kg clarithromycin b.i.d., not exceeding a maximum dose of 500 mg b.i.d.
Treatment with clarithromycin should continue as long as clinical benefit is demonstrated. The addition of other antimycobacterial agents may be of benefit. (See Table 4.)

Click on icon to see table/diagram/image

Renal Impairment: In children with creatinine clearance less than 30 ml/min/1.73 m2, the dosage of clarithromycin should be reduced by one-half, i.e., up to 250 mg once daily, or 250 mg twice daily in more severe infections. Dosage should not be continued beyond 14 days in these patients.
Preparation for Use: See Special precautions for disposal and other handling under Cautions for Usage.
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