Known hypersensitivity to clarithromycin, erythromycin or any macrolide antibiotic, or to any component of the product.
Patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior use of clarithromycin.
Patients with a history of QT prolongation or ventricular cardiac arrhythmia, including torsades de pointes.
Concomitant administration with cisapride, pimozide, astemizole, terfenadine, and ergotamine or dihydroergotamine which may result in cardiac arrhythmias (QT prolongation, ventricular tachycardia, ventricular fibrillation, and torsades de pointes) leading to death.
Concomitant administration with simvastatin or lovastatin.
Concomitant administration with ticagrelor or ranolazine.
Concomitant administration of clarithromycin and colchicine in patients with renal or hepatic impairment.