Koxib

Koxib

celecoxib

Manufacturer:

Lloyd

Marketer:

Randril
Concise Prescribing Info
Contents
Celecoxib
Indications/Uses
Relief of the signs & symptoms of OA & RA in adults. As adjunct for reduction of number of adenomatous colorectal polyps in familial polyposis.
Dosage/Direction for Use
OA 200 mg daily as a single dose or in divided doses. May give 200 mg bid if necessary. RA 100-200 mg bid. Ankylosing spondylitis Initially 200 mg daily as a single dose or in 2 divided doses. Pain & dysmenorrhea Initially 400 mg followed by 200 mg additional dose if necessary, on the 1st day, then 200 mg bid thereafter. Adenomatous colorectal polyps 400 mg bid.
Administration
Should be taken with food.
Contraindications
Hypersensitivity including those in whom attacks of angioedema, rhinitis & urticaria have been precipitated by aspirin, NSAIDs or sulfonamides. Severe heart failure; inflammatory bowel disease; peptic ulcer. Patients w/ history of CVA, MI, CABG, uncontrolled HTN, CHF NYHA II-IV. Renal (CrCl <30 mL/min) & severe hepatic impairment. Pregnancy & lactation.
Special Precautions
Should not be given in patients w/ history of hypersensitivity to sulfonamides & NSAIDs. Stop intake if skin rash & signs of hypersensitivity occurs. Patients w/ asthma; ischemic heart disease & risk factors for heart disease, HTN, hyperlipidemia, diabetes, smoking & peripheral arterial disease. Potential GI (gastric & liver) & renal toxicities.
Adverse Reactions
GI disturbances eg, GI discomfort, nausea & diarrhea,
Drug Interactions
Changes in plasma conc w/ CYP450 isoenzyome CYP2C9 inhibitors. Increased plasma conc w/ fluconazole.
MIMS Class
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
ATC Classification
M01AH01 - celecoxib ; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, coxibs.
Presentation/Packing
Form
Koxib cap 200 mg
Packing/Price
100's
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