Undesirable effects involving stomach and intestines include: constipation, diarrhea, nausea, vomiting, abdominal and gas-related discomfort, decreased appetite, dry mouth, heartburn, and loss of taste.
Famotidine may also cause the following skin reactions: acne, itching, red, itchy patches on the skin (hives), rash and dry skin.
Headache, dizziness, weakness, fatigue, muscle weakness, seizures, insomnia, drowsiness, depression, confusion, disorientation, anxiety, decreased sexual desire, and hallucinations have been reported.
Famotidine may also cause kidney problems (e.g., increased serum creatinine concentration and abnormal amounts of protein in the urine) and liver disease such as yellowing of the skin (jaundice).
Other undesirable effects include: fever, hypertension, flushing, muscle cramps, pain in the joints, ringing in the ears (tinnitus), and community-acquired pneumonia.
Antacids: Flatulence from increased carbon dioxide may occur in some patients.
Calcium carbonate can stimulate acid rebound in some people. Acid rebound causes stomach to produce even more acid, making heartburn worse. This, however, is very rare.
Excessive doses of calcium carbonate and magnesium hydroxide may result in high calcium and magnesium levels in the blood in patients with kidney impairment.
Alkalosis (excess base in body fluids) may also occur with excessive doses of antacid.
The combination of magnesium hydroxide and calcium carbonate balances the side effects of diarrhea from magnesium hydroxide and constipation from calcium carbonate.
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