Kwell

Permethrin.

Shampoo: Kwell contains 1% w/w permethrin (10 mg/g).
Lotion: Kwell contains 5% w/w permethrin (50 mg/g).

Pharmacotherapeutic Group: Delousing agent-pyrethroid. ATC Code: P03AC04.
Pharmacology: Pharmacodynamics: The potent insecticidal action of permethrin arises from repeated depolarization of the neurons and leads to a reduction in neuronal excitability causing sensory hyperexcitability, incoordination, prostration, paralysis and eventual death.
Pharmacokinetics: Permethrin is not rapidly absorbed transdermally and that the extent of systemic exposure is very low. Plasma concentrations of permethrin are undetectable. The small amount of permethrin that is absorbed is rapidly metabolized and excreted. Distribution of the drug into major body tissues is not of great concern.

Shampoo: Treatment of head lice and their eggs and prevention for those at risk.
Lotion: Scabicide. Treatment of scabies and crab lice infestation.

Shampoo: Treatment of Head Lice and their Eggs: Wet hair. Shake bottle, apply and lather enough Kwell shampoo to cover entire hair and scalp including areas behind ears and nape of the neck. Leave for 10 min before rinsing the hair thoroughly with water. Towel dry. Check any other family members and treat them if necessary to prevent re-infection. Kwell shampoo is suitable for use by adults and children >6 months.
Lotion: Apply to clean, dry, cool skin. If warm bath was taken prior to treatment, allow skin to cool before applying Kwell lotion.
Treatment of Scabies: Adults and children >2 years: Apply to the whole body excluding the head and paying particular attention to the areas between the fingers and the toes and under fingernails and toenails, wrists, armpits, buttocks and genital area.
Children 2 months to 2 years: Apply over the whole body as directed for the adults and children >2 years, but should include the face, neck, scalp and ears. Care must be taken to avoid the vicinity of the mouth where it could be licked off and areas close to the eyes.
Treatment of Crab Lice: Adults & children >2 months: Sufficient lotion should be applied to cover the pubic region, peri-anal area, inner thighs down to the knees and any hair on the trunk which extends to the pubic area. Any facial hair except the eyelashes and eyebrows should also be treated if found to be infested with lice or their eggs. It is recommended that any lice or their eggs found in eyelashes should be removed with a pair of tweezers. A second treatment should be administered if live lice are found on any previously treated area 7 days after treatment. During the treatment period, Kwell lotion should be re-applied to the hands if they are washed with soap and water. The whole body should be washed thoroughly 8-12 hrs after treatment.

Known hypersensitivity reactions to permethrin, other pyrethroids or pyrethrins and any components of Kwell.

Lotion: If eye contact occurs, wash out promptly and thoroughly with water. The use of corticosteroids should be withheld prior to or during the treatment of permethrin lotion.
Shampoo: If eye contact occurs, wash out promptly and thoroughly with water. If severe or prolonged signs and symptoms of scalp irritation, skin discomfort or other undesirable effects occur in association with the use of permethrin shampoo, it should be brought to the attention of a doctor or pharmacist.
If accidentally swallowed by a child, consult a doctor immediately. Gastric lavage should be considered within 2 hrs of ingestion and management should relate to treatment of alcoholic intoxication. For pregnant or lactating mothers, consult the doctor before use.

For external use only.

Store below 30°C. Protect from light (shampoo).

Topical Antifungals & Antiparasites

P03AC04 - permethrin ; Belongs to the class of pyrethrines, including synthetic compounds used as ectoparasiticides.

Non-Rx