Lanreotide: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the local prescribing information.

Generic Medicine Info

Indications and Dosage

Intramuscular
Acromegaly, Carcinoid syndrome, Thyrotrophic adenoma

Adult: Initially, 30 mg by IM depot inj every 14 days. For acromegaly and carcinoid syndrome: May increase to 30 mg every 7-10 days; for thyrotrophic adenoma: May increase to 30 mg every 10 days.

Subcutaneous
Carcinoid syndrome, Acromegaly

Adult: 60, 90 or 120 mg by deep SC inj every 28 days. For acromegaly patients who responded: May reduce gradually to maintenance dose of 120 mg given at intervals of up to 56 days. For those who are not adequately controlled: Max dose of 120 mg once every 28 days may be used.

Renal Impairment

Subcutaneous:
Moderate to severe impairment: Initially, 60 mg by deep SC inj every 28 days for 3 mth; then adjust dose according to response.

Hepatic Impairment

Subcutaneous:
Moderate to severe impairment: Initially, 60 mg by deep SC inj every 28 days for 3 mth; then adjust dose according to response.

Special Precautions

Pregnancy, lactation. Check for gallstones before prolonged therapy and every 6-12 mth during treatment. Monitor for signs of tumour expansion. Monitor thyroid function.

Adverse Reactions

Transient local reaction at inj site, diarrhoea, steatorrhoea, abdominal discomfort, flatulence, anorexia, nausea, vomiting, gallstones (prolonged use), hypoglycaemia.

Pregnancy Category (US FDA)

Parenteral/SC: C

Drug Interactions

May reduce intestinal absorption of coadministered drugs. May reduce serum concentration of ciclosporin. May increase bioavailability of bromocriptine. Dosage of insulin or oral hypoglycaemic drugs, β-blockers, calcium-channel blockers, or agents to control fluid and electrolyte balance may need to be adjusted.

Action

Description: Lanreotide is a somatostatin analogue which inhibits the release of growth hormone by binding to human somatostatin receptors (SSTR2 and 5). It also inhibits various endocrine, neuroendocrine, exocrine and paracrine functions.
Pharmacokinetics:
Absorption: Absolute bioavailability: 50-80%.
Excretion: IV: 2.5 hr (terminal half-life).

Storage

Store at 2-8°C (36-46°F). Do not freeze.

MIMS Class

Trophic Hormones & Related Synthetic Drugs

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