Larfen

Larfen

raloxifene

Manufacturer:

Mega Lifesciences

Distributor:

Metro Drug
Concise Prescribing Info
Contents
Raloxifene HCl
Indications/Uses
Treatment & prevention of osteoporosis in postmenopausal women.
Dosage/Direction for Use
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Active or past history of venous thromboembolic events including DVT, pulmonary embolism & retinal vein thrombosis. Hepatic & severe renal impairment; unexplained uterine bleeding. Patients w/ signs & symptoms of endometrial cancer. Women of childbearing potential.
Special Precautions
Not to be used for primary or secondary prevention of CV disease. Increased risk of venous thromboembolism. Discontinue at least 72 hr prior to & during prolonged immobilization (eg, post surgical recovery, prolonged bed rest) & resume therapy only after fully ambulatory. Consider risk-benefit balance in women at risk of thromboembolic disease for other reasons eg, CHF, superficial thrombophlebitis & active malignancy; at risk for stroke (eg, prior stroke or transient ischemic attack, atrial fibrillation, HTN, cigarette smoking). History of breast cancer & use of oral estrogen-induced hypertriglyceridemia (>5.6 mmol/L). Unexplained uterine bleeding & breast abnormality. Monitor serum bilirubin, γ-glutamyl transferase, alkaline phosphatase, ALT & AST. Not recommended for premenopausal use & use for men. Moderate & mild renal impairment. Hepatic impairment. Not recommended during pregnancy & lactation. Childn.
Adverse Reactions
Vasodilation (hot flushes); flu syndrome. Leg cramps; peripheral oedema.
Drug Interactions
Decreased prothrombin time w/ warfarin. Reduced absorption & enterohepatic cycling w/ cholestyramine (or other anion exchange resins). Reduced peak conc w/ ampicillin. May increase hormone-binding globulin conc of sex steroids-, thyroxine- & corticosteroid-binding globulin.
ATC Classification
G03XC01 - raloxifene ; Belongs to the class of selective estrogen receptor modulators.
Presentation/Packing
Form
Larfen FC tab 60 mg
Packing/Price
28's
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