Letero

Letero Drug Interactions

letrozole

Manufacturer:

Hetero Labs

Distributor:

Camber
Full Prescribing Info
Drug Interactions
Tamoxifen: Coadministration of Letrozole and tamoxifen 20 mg daily resulted in a reduction of letrozole plasma levels of 38% on average. Clinical experience in the second-line breast cancer trials indicates that the therapeutic effect of Letrozole therapy is not impaired if Letrozole is administered immediately after tamoxifen.
Cimetidine: A pharmacokinetic interaction study with cimetidine showed no clinically significant effect on letrozole pharmacokinetics.
Warfarin: An interaction study with warfarin showed no clinically significant effect of letrozole on warfarin pharmacokinetics.
Other anticancer agents: There is no clinical experience to date on the use of Letrozole in combination with other anticancer agents.
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