Letoripe Dosage/Direction for Use







Full Prescribing Info
Dosage/Direction for Use
Adult and Elderly Patients: The recommended dose of Letrozole tablets is one 2.5 mg tablet administered once a day, without regard to meals. Treatment with Letrozole tablets should continue until tumor progression is evident. No dose adjustment is required for elderly patients. Patients treated with Letrozole tablets do not require glucocorticoid or mineralocorticoid replacement therapy.
Renal Impairment: No dosage adjustment is required for patients with renal impairment if creatinine clearance is >10 mL/min.
Hepatic Impairment: Although letrozole blood concentrations were modestly increased in subjects with moderate hepatic impairment due to cirrhosis, no dosage adjustment is recommended for patients with mild-to-moderate hepatic impairment. Patients with severe impairment of liver function have not been studied. Because letrozole is eliminated almost exclusively by hepatic metabolism, patients with severe impairment of liver function should be dosed with caution.
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