Levores

Levores

levofloxacin

Manufacturer:

Prosweal Healthcare

Distributor:

Prosweal Healthcare
Concise Prescribing Info
Contents
Levofloxacin hemihydrate
Indications/Uses
Infections w/ susceptible microorganisms eg, community acquired pneumonia, complicated UTI. Oral: Acute maxillary sinusitis & bacterial exacerbations of chronic bronchitis, uncomplicated skin & skin structure infections. IV: Skin & soft tissue infections.
Dosage/Direction for Use
Oral 250-500 mg once daily for 7-14 days. Renal impairment CrCl 20-49 mL/min Initially 500 mg, then 250 mg every 24 hr; 10-19 mL/min, hemodialysis & chronic ambulatory peritoneal dialysis Initially 500 mg, then 250 mg every 48 hr. IV 250 or 500 mg doses infused slowly over 60 min & 750 mg doses infused slowly over 90 min. Renal impairment CrCl 20-49 mL/min Initially 500 mg, then 250 mg every 24 hr; 10-19 mL/min, hemodialysis & chronic ambulatory peritoneal dialysis Initially 500 mg, then 250 mg every 48 hr.
Administration
May be taken with or without food: Take at least 2 hr before or after Fe salts, antacids & sucralfate. Ensure adequate fluid intake.
Contraindications
Hypersensitivity to levofloxacin or other antimicrobial agents.
Special Precautions
Potential increased incidence of osteochondrosis. Patients w/ known or suspected CNS disorder that may predispose to seizures or lower seizure threshold (eg, severe cerebral arteriosclerosis, epilepsy) or in presence of other risk factors (eg, certain drug therapy, renal dysfunction). Immediately discontinue use upon occurrence of occasionally fatal hypersensitivity &/or anaphylactic reactions. Consider diagnosis of pseudomembranous colitis in patients w/ diarrhea. Overgrowth of clostridia. Discontinue use if hypoglycemia; inflammation or rupture of a tendon occurs. Maintain adequate hydration to prevent formation of highly concentrated urine. Moderate to severe phototoxicity reaction; discontinue use if this occurs. Disturbance of blood glucose, including symptomatic hyper- & hypoglycemia. Periodic assessment of renal, hepatic, hematopoietic function. Renal insufficiency. Pregnancy & lactation. Childn & adolescents (<18 yr).
Adverse Reactions
Diarrhea, nausea, vaginitis, flatulence, pruritis, rash, abdominal pain, insomnia, taste perversion, vomiting, anorexia, anxiety, constipation, edema, fatigue, headache, increased sweating, leukorrhea, malaise, nervousness, sleep disorders, tremor, urticaria. Allergic pneumonitis, anaphylactic shock, anaphylactoid reaction, dysphonia, abnormal EEG, encephalopathy, eosinophilia, erythema multiforme, hemolytic anemia, multi-system organ failure, palpitation, paresthesia, Stevens-Johnson syndrome, tendon rupture, vasodilation.
Drug Interactions
Decreased absorption w/ antacids containing Al & Mg, & w/ drugs containing Fe. May increase the risk of CNS stimulation & convulsive seizures w/ NSAIDs. May cause disturbances of blood glucose including hyper- & hypoglycemia w/ antidiabetic agent.
MIMS Class
ATC Classification
J01MA12 - levofloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
Presentation/Packing
Form
Levores film-coated tab 500 mg
Packing/Price
10's;60's
Form
Levores soln for infusion 5 mg/mL
Packing/Price
100 mL x 1's
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