Logimax

Logimax

Manufacturer:

AstraZeneca

Distributor:

Zuellig
Concise Prescribing Info
Contents
Felodipine 5 mg, metoprolol 50 mg
Dosage/Direction for Use
Initially 1 tab once daily in the morning. May be increased to 1 tab bid if required.
Administration
May be taken with or without food: Swallow whole, do not divide/chew/crush. May be taken w/ a light meal w/ a low fat & carbohydrate content.
Contraindications
Hypersensitivity to felodipine, metoprolol, other dihydropyridines or β-blockers. Unstable angina pectoris. Degree II & III AV block. Unstable uncompensated heart failure (pulmonary edema, hypoperfusion or hypotension), continuous or intermittent inotropic therapy w/ β-receptor agonism. Symptomatic bradycardia or hypotension. Sick sinus syndrome. Cardiogenic shock. Severe peripheral vascular disease w/ threat of gangrene. Do not administer to patients w/ suspected acute MI w/ heart rate <45 beats/min, P-Q interval >0.24 sec or systolic BP <100 mmHg. Pregnancy.
Special Precautions
Not to be used for 1st treatment of previously untreated patients; patients w/ latent or manifest cardiac insufficiency w/o concomitant treatment. May affect carbohydrate metabolism or mask hypoglycemia. AV conduction time may exacerbate (possibly leading to AV block). Prinzmetal's angina. Bronchial asthma or COPD. May make treatment of anaphylactic reaction more difficult. Pheochromocytoma. Avoid concomitant use w/ CYP3A4 inducers, potent CYP3A4 inhibitors & grapefruit juice. Dot not w/draw in patients who are undergoing surgery. Severely impaired renal function (GFR <30 mL/min). Impaired hepatic function. May impair ability to drive or operate machinery. Lactation.
Adverse Reactions
Felodipine: Ankle swelling, headache, dizziness, fatigue; facial redness; nausea. Metoprolol: Fatigue, headache, dizziness; peripheral cold in extremities, bradycardia, palpitations; abdominal pain, nausea, vomiting, diarrhea, constipation.
Drug Interactions
Felodipine: May affect plasma conc w/ drugs that inhibit or induce CYP3A4. Increased metabolism w/ CYP450 inducers eg, carbamazepine, phenytoin, phenobarb, rifampicin & St. John's wort (Hypericum perforatum). Increased Cmax & AUC w/ CYP450 inhibitors eg, itraconazole, ketoconazole, erythromycin & HIV protease inhibitors; grapefruit juice; cyclosporin; cyclosporin & cimetidine. Increased conc of tacrolimus. Metoprolol: May affect plasma conc w/ drugs that inhibit CYP2D6 eg, quinidine, terbinafine, paroxetine, fluoxetine, sertraline, celecoxib, propafenone & diphenhydramine. Induced metabolism w/ barbiturates, rifampicin. Inhibits metabolism w/ propafenone, quinidine. Bradycardia & fall in BP w/ verapamil. Additive -ve inotropic effects w/ class I antiarrhythmics eg, disopyramide. Reduced clearance & potentiated effects w/ diphenhydramine. Potentiated effects w/ sudden withdrawal of clonidine. Pronounced bradycardia w/ diltiazem, amiodarone. Counteract the antihypertensive effect w/ NSAIDs. May cause paradoxical hypertensive reactions w/ high dose of phenylpropanolamine. Marked HTN & bradycardia w/ epinephrine. Pronounced sinus bradycardia w/ amiodarone. Potentiated cardiodepressive effects w/ inhalation anesth. Other β-receptor blockers (eg, eye drops) or MAO inhibitors.
MIMS Class
Beta-Blockers / Calcium Antagonists
ATC Classification
C07FB02 - metoprolol and felodipine ; Belongs to the class of selective beta-blocking agents in combination with other antihypertensives. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Logimax ER tab
Packing/Price
100's
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