Prophylaxis of DVT w/c may lead to pulmonary embolism. Prophylaxis of ischemic complications of unstable angina & non-Q-wave MI when currently administered w/ aspirin. Prevention of thrombus formation in extracorporeal circulation during hemodialysis.
AdultAbdominal surgery 40 mg once daily SC. Initial dose given 2 hr pre-op then for 7-10 days. Hip or knee replacement surgery 30 mg every 12 hr SC. Initial dose given 12-24 hr pre-op. For hip replacement, 12 (±3) hr pre-op. Continued for 3 wk at a dose of 40 mg once daily SC. Risk of thromboembolic complications during acute illness 40 mg once daily SC for 6-11 days. Unstable angina & non-Q-wave MI 1 mg/kg SC 12 hrly for 2-8 days. DVT w/ or w/o pulmonary embolism 1 mg/kg 12 hrly. Prevention of thrombus formation in extracorporeal circulation during hemodialysis 1 mg/kg. Patient at high-risk of hemorrhage 0.5 mg/kg. Patient w/ double vascular access 0.75 mg/kg.