Losmac

Losartan K

HTN. Patients who are unable to tolerate ACE inhibitors. Heart failure & MI; diabetic nephropathy in type 2 DM.

Initially 50 mg once daily, increased if necessary after several wk to 100 mg once daily. Elderly >75 yr, moderate to severe renal impairment, intravascular vol depletion Initially 25 mg once daily.

May be taken with or without food.

Hypersensitivity. Pregnancy & lactation.

Renal artery stenosis. Hypotension in patients w/ vol depletion (eg, those who have received high-dose diuretic therapy). Monitor serum K conc especially in the elderly & patients w/ renal impairment. Avoid concomitant use w/ K-sparing diuretics. Hepatic impairment. Not recommended during pregnancy (1st trimester).

Anemia, thrombocytopenia, hypersensitivity & anaphylactic reactions, angioedema, vasculitis; depression; dizziness, somnolence, headache, sleep disorders, paraesthesia, migraine, dysgeusia; vertigo, tinnitus; palpitations, angina pectoris, syncope, atrial fibrillation, CV accident; hypotension; dyspnea, cough; abdominal pain, obstipation, diarrhea, nausea, vomiting; pancreatitis, hepatitis, liver function abnormalities; urticaria, pruritus, rash, photosensitivity; myalgia, arthralgia, rhabdomyolysis; renal impairment, renal failure; erectile dysfunction/impotence; asthenia, fatigue, edema, malaise.

Increased hypotensive action w/ other antihypertensive agents. May increase risk of hypotension w/ other substances which may induce hypotension as an adverse reaction (eg, TCAs, antipsychotics, baclofen & amifostine). Decreased exposure w/ fluconazole. Reduction in plasma conc w/ rifampicin. May increase serum K w/ other medicinal products which retain K (eg, K-sparing diuretics: amiloride, triamterene spironolactone) or K levels (eg, heparin), K supplements or salt substitutes containing K. Reversible increase in serum lithium conc & toxicity. Attenuation of the antihypertensive effects w/ NSAIDs (ie, selective COX-2 inhibitors, ASA at anti-inflammatory doses & non-selective NSAIDs). Increased risk of worsening renal function, including possible acute renal failure & increase in serum K especially in patients w/ poor preexisting renal function w/ diuretics & NSAIDs. Higher frequency of adverse events eg, hypotension, hyperkalemia & decreased renal function (including acute renal failure) w/ ACE inhibitors or aliskiren.

Angiotensin II Antagonists

C09CA01 - losartan ; Belongs to the class of angiotensin II receptor blockers (ARBs). Used in the treatment of cardiovascular disease.

Rx