Metro Drug


Macropharma Corp
Concise Prescribing Info
Accelerate the recovery of neutropenia in patients receiving myelosuppressive chemotherapy & neutropenia in patients w/ acute myelogenous leukemia (AML) receiving induction chemotherapy.
Dosage/Direction for Use
SC Myelosuppressive chemotherapy Adult 100 mcg/m2. Childn 50 mcg/m2. Once daily for 10 days. IV including IV drip infusion Adult & childn w/ AML receiving induction chemotherapy 200 mcg/m2 once daily.
Hypersensitivity to filgrastim or G-CSF drug. Myeloid leukemia.
Special Precautions
Hypersensitivity. Patient w/ allergic disposition, serious hepatic & renal failure & cardiopulmonary function. Perform periodic blood test to prevent excessive increase of neutrophils. Discontinue if anaphylaxis occur; increase in myeloblasts is observed. Skeletal & lumbar pain may occur. Increase palpation of neutrophil. Myelodysplastic syndrome. Possibility of HIV proliferation. Patients receiving concurrent radiation therapy. Mobilization of progenitor cells to peripheral blood. Facilitatory effect on proliferation of several strains of human bladder cancer & osteosarcoma; temporary cardiac arrest; contaminated peripheral blood progenitor cells harvested from patients w/ breast cancer, malignant lymphoma or myeloma. Pregnancy. Childn. Elderly.
Adverse Reactions
Peripheral blood progenitor cells mobilization donor: Lumbar pain, headache, arthralgia, increased LDH, ALP, uric acid & CRP, leukopenia/neutropenia, thrombocytopenia. Neutropenic patient: Skeletal pain, fever, lumbar pain, abnormal hepatic function, increased LDH, ALP, ALT & AST. Myalgia; stomachache; rigor, edema (limbs & face); neuropathy; itch, wheal, skin trouble; nasal bleeding, sore throat.
Drug Interactions
Caution w/ antithrombotic drugs eg, aspirin.
ATC Classification
L03AA02 - filgrastim ; Belongs to the class of colony stimulating factors. Used as immunostimulants.
Macroleuco soln for inj 300 mcg/1.2 mL
10 × 1's (P4,000/vial)
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