MaXine

MaXine

venlafaxine

Manufacturer:

Pell Tech Healthcare

Distributor:

InnoGen Pharmaceuticals
Concise Prescribing Info
Contents
Venlafaxine HCl
Indications/Uses
Major depressive disorder, generalized anxiety, social anxiety & panic disorder.
Dosage/Direction for Use
Initial single dose: 37.5 mg/day, increased to 75 mg/day. Max: 225 mg/day, in increments up to 75 mg/day at not <4 days interval.
Administration
Should be taken with food: Take in the morning or in the evening at approx the same time each day. Swallow whole w/ fluid. Do not divide/crush/chew/placed in water. May be administered by opening the cap & sprinkling the entire content on a spoonful of applesauce. Swallow the mixt immediately w/o chewing & followed w/ a glass of water to ensure complete swallowing of the pellets.
Contraindications
Hypersensitivity. Concomitant or w/in 14 days of MAOI therapy.
Special Precautions
Closely monitor for clinical worsening, suicidality or unusual behavioral changes in patients w/ major depressive disorder. Psychiatric & family history of suicide, bipolar disorder & depression. Avoid use w/ bipolar depression. Hyponatremia. Co-administration w/ metoprolol, CNS-active drugs & triptans. Renal & hepatic impairment. Pregnancy & lactation. Childn. Elderly.
Adverse Reactions
Chest pain substernal, chills, fever, neck pain; migraine, tachycardia; increased appetite; ecchymosis; edema, wt gain; amnesia, confusion, depersonalization, hypesthesia, thinking abnormal, trismus, vertigo; increased cough, dyspnea; pruritus; abnormality of accommodation, mydriasis, taste pervesion; albuminuria, impaired urination.
Drug Interactions
Reduced BP lowering effect of metoprolol. Increased AUC of risperidone. Decreased AUC & Cmax of indinavir. QT  prolongation &/or ventricular arrhythmias w/ antibiotics & some antipsychotics. False +ve urine immunoassay screening tests for phencyclidine & amphetamine.
MIMS Class
ATC Classification
N06AX16 - venlafaxine ; Belongs to the class of other antidepressants.
Presentation/Packing
Form
MaXine SR cap 75 mg
Packing/Price
30's
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