Monitor blood count on higher doses and prolonged duration. Periodic assessment of haematologic, hepatic and renal function. Check for helminth ova in faeces within 3-4 weeks following initial therapy.
Symptoms: Abdominal cramps, nausea, vomiting, diarrhoea; rarely, alopecia, reversible liver function abnormalities, hepatitis, agranulocytosis, neutropenia, glomerulonephritis. Management: Administration of activated charcoal may be given.
Increased plasma concentration with cimetidine. Decreased serum concentration with carbamazepine, fosphenytoin, phenytoin. Potentially Fatal: Co-administration of metronidazole may increase risk of Stevens-Johnson syndrome/toxic epidermal necrolysis.
Increased serum levels with food.
Description: Mebendazole, a benzimidazole carbamate derivative, is an anthelmintic with activity against most nematodes and some other worms by interfering the formation of helminth microtubules and causes ultrastructural degenerative changes in the intestine. It selectively and irreversibly blocks glucose uptake and disrupts digestive and reproductive functions resulting to immobilization, inhibition of egg production and death of the helminth. Pharmacokinetics: Absorption: Poorly absorbed from the GI tract. Increased serum level with food. Time to peak plasma concentration: 1.5-7.25 hours. Distribution: Crosses blood-brain barrier and enters breast milk. Volume of distribution: 1-2 L/kg. Plasma protein binding: 90-95% Metabolism: Extensively metabolised in the liver via first pass effect. Primary metabolite: 2-amine hydrolysed metabolite. Excretion: Mainly via faeces; urine (<2%). Elimination half-life: 3-6 hours.
P02CA01 - mebendazole ; Belongs to the class of benzimidazole derivative agents. Used as antinematodal.
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