Each capsule contains: Mecobalamin 500 mcg.
Each 1 mL ampoule contains: Mecobalamin 500 mcg.
Pharmacology: Pharmacodynamics: Mechanism of Action: Biochemically, Mecobalamin is a B12 co-enzyme with an active methyl base. It participates in transmethylation reactions and is the most active of B12 homologues in the body with respect in to nucleic acid, protein, and lipid metabolism. Mecobalamin acts to repair damaged nerve tissue in nerve disorders, e.g. axonal degeneration and derhyelination, and it is involved in erythroblast maturation, promotion of erythroblast division, and heme synthesis, thus Mecobalamin repairs the blood status in megaloblastic anemia condition.
Treatment of peripheral neuropathies, megaloblastic anemia and other manifestations of Vitamin B12 deficiency.
Capsule: Take 1 capsule three times a day.
Solution for injection: The usual adult dosage is 1 ampoule, equivalent to 500 mcg of Mecobalamin administered IM or IV three time a week.
The dosage should be adjusted according to the age of the patient and severity of symptoms.
Patients with hypersensitivity to Mecobalamin.
Discontinue medication if there is no response after administration for several months.
discontinue the administration of this drug if symptoms of hypersensitivity, e.g. eruption, occurs.
Headache; sweating or fever may rarely occur.
Solution for injection:
Pain and induration may sometimes occurs at the site of injection.
Loss of appetite, nausea, diarrhea or other symptoms of gastrointestinal upsets may appear.
Absorption of Vitamin B12 from the gastrointestinal tract may be reduced by Neomycin, Aminosalicytic acid, Histamine H2-antagonists, Omeprazole, and Colchicine. Serum concentrations may be decreased by use of oral contraceptives. Many of these interactions are unlikely to be of clinical significance but should be taken into account when performing assays for blood concentrations. Parenteral Chloramphenicol may attenuate the effect of vitamin B12 in anemia.
Store at temperatures not exceeding 30°C.
Solution for injection: Protect from light.
B03BA05 - mecobalamin ; Belongs to the class of vitamin B12 (cyanocobalamin and analogues). Used in the treatment of anemia.
Cap 500 mcg x 100's. Soln for inj 500 mcg/mL (red color and clear solution) x 1 mL x 10's.