Mel-OD should be used with caution in patients with a history of allergy or development of asthma with aspirin or other NSAIDs. Mel-OD should be used with extreme caution in patients with severe hepatic and end-stage renal failure. Patients with congestive heart failure, liver cirrhosis, nephrotic syndrome, hypovolemia and renal insufficiency should receive Mel-OD with caution due to the risk of precipitation of renal failure in such patients. Patients with gastritis or past history of ulcer disease should also receive Mel-OD with caution for the fear of precipitating gastrointestinal bleeding in such patients.
Use in children: The safety of Mel-OD in children <15 years has not been established.