Increased hypoglycaemic effect w/ possible onset of hypoglyceamic symptoms or even coma. Reduced elimination w/ phenylbutazone. Inhibition of compensatory reactions w/ alcohol. Potentiation of the blood glucose lowering effect w/ other antidiabetics (eg, insulin, acarbose, biguanide), β-blockers, fluconazole, ACE inhibitors (captopril, enalapril), H2
receptor antagonists, MAOIs, sulphonamides & NSAIDS. May increase blood glucose levels w/ danazol; chlorpromazine; glucocorticoids; ritodrine, salbutamol, terbutaline. Potentiation of anticoagulation w/ warfarin. Gliclazide: Potentiation of hypoglycaemic effect w/ salicylates, sulphonamides, octreotide, azaprapazone, sulfinpyrazone. May accelerate metabolism w/ aminoglutethimide, testosterone, tetracycline, chloramphenicol, clofibrate, disopyramide, cimetidine. Diminished effects w/ rifamycins, OCs, thiazide diuretics, diazoxide, phenothiazine, thyroid hormones, loop diuretics & abuse of laxatives. Metformin: Increased risk of lactic acidosis w/ alcohol. Intrinsic hyperglycaemic activity w/ glucocorticoids (systemic & local) β2
-agonists & diuretics. May decrease blood glucose levels w/ ACE inhibitors.