Melanov-M

Melanov-M

Manufacturer:

Brown & Burk Phils

Distributor:

Brown & Burk Phils
Concise Prescribing Info
Contents
Gliclazide 80 mg, metformin HCl 500 mg
Indications/Uses
NIDDM; diabetes w/ or w/o obesity in adults.
Dosage/Direction for Use
1-2 tab once or bid. Max: 4 tab/day.
Administration
Should be taken with food.
Contraindications
Hypersensitivity. IDDM, renal or hepatic failure, alcoholism, NIDDM complicated by severe ketosis & acidosis, diabetic precoma & coma, patients undergoing surgery, after severe trauma or during infections, COPD, CHF, cardiac failure, peripheral vascular disease. Pregnancy.
Special Precautions
Adjust dose of combination according to blood & urinary glucose levels during 1st few mth. Lactic acidosis in patients w/ renal or liver disease. Hypoglycemia.
Adverse Reactions
Nausea, vomiting, diarrhea, abdominal pain. Gliclazide: Hypoglycemia. GI disturbance eg, dyspepsia, constipation.
Drug Interactions
Increased hypoglycaemic effect w/ possible onset of hypoglyceamic symptoms or even coma. Reduced elimination w/ phenylbutazone. Inhibition of compensatory reactions w/ alcohol. Potentiation of the blood glucose lowering effect w/ other antidiabetics (eg, insulin, acarbose, biguanide), β-blockers, fluconazole, ACE inhibitors (captopril, enalapril), H2 receptor antagonists, MAOIs, sulphonamides & NSAIDS. May increase blood glucose levels w/ danazol; chlorpromazine; glucocorticoids; ritodrine, salbutamol, terbutaline. Potentiation of anticoagulation w/ warfarin. Gliclazide: Potentiation of hypoglycaemic effect w/ salicylates, sulphonamides, octreotide, azaprapazone, sulfinpyrazone. May accelerate metabolism w/ aminoglutethimide, testosterone, tetracycline, chloramphenicol, clofibrate, disopyramide, cimetidine. Diminished effects w/ rifamycins, OCs, thiazide diuretics, diazoxide, phenothiazine, thyroid hormones, loop diuretics & abuse of laxatives. Metformin: Increased risk of lactic acidosis w/ alcohol. Intrinsic hyperglycaemic activity w/ glucocorticoids (systemic & local) β2-agonists & diuretics. May decrease blood glucose levels w/ ACE inhibitors.
MIMS Class
ATC Classification
A10BD02 - metformin and sulfonylureas ; Belongs to the class of combinations of oral blood glucose lowering drugs. Used in the treatment of diabetes.
Presentation/Packing
Form
Melanov-M tab
Packing/Price
30's (P480/box)
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in