Memantine hydrochloride can be taken with or without food.
Recommended Starting Dose: 5 mg once a day.
Recommended Maximum Dose: 20 mg per day.
The dose should be increased in 5 mg increments over the first four weeks of treatment reaching the recommended maintenance dose as follows: See table.
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The minimum recommended interval between dose increase is one week.
Recommended Maintenance Dose: 20 mg per day.
Hepatic Impairment: In patients with mild or moderate hepatic impairment (Child-Pugh A and Child-Pugh B), no dosage adjustment is required. No data is available for patients with severe hepatic impairment. Administration of memantine is not recommended in patients with severe hepatic impairment.
Renal Impairment: Patients with mild renal impairment (CLcr: 50 to 80 mL/min): No dosage adjustment is required in patients with mild renal impairment.
Patients with moderate renal impairment (CLcr: 30 to 49 mL/min): 10 mg per day.
If well-tolerated after at least seven days of treatment, the dose can be increased up to 20 mg per day according to the standard titration scheme.
Patients with severe renal impairment (CLcr: 5 to 29 mL/min): 10 mg per day.
Elderly (over 65 years old): 20 mg per day.
Or, as prescribed by a physician.