Meropenem (MEROPEVEX) is given by slow injection over 3 to 5 minutes or by infusion over 15 to 30 minutes in a usual adult dose of 0.5 to 1 g every 8 hours, increased to 2 g every 8 hours for meningitis; doses of up to 2 g every 8 hours have also been used in cystic fibrosis.
Children over 3 months of age and weighing less than 50 kg may be given 10 to 20 mg/kg every 8 hours, increased to 40 mg/kg every 8 hours for meningitis. Doses of 25 to 40 mg/kg every 8 hours have been used in children with cystic fibrosis.
Dosage adjustment for patients with Renal Impairment: Meropenem (MEROPEVEX) should be reduced in patients with renal impairment. The following doses may be given based on creatinine clearance (CC): CC 26 to 50 mL/minute: the usual dose given every 12 hours.
CC 10 to 25 mL/minute: one-half the usual dose every 12 hours.
CC less than 10 mL/minute: one-half the usual dose every 24 hours.
Direction for Reconstitution: For intravenous bolus injection, MEROPEVEX should be dissolved in sterile water for injection (5 mL per 250 mg of Meropenem). This produces a concentration of approximately 50 mg/mL. Solutions that are ready to use are clear, and colorless or pale yellow.