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Probenecid inhibits the renal excretion of meropenem thereby increasing its plasma concentrations and prolonging its elimination half-life.
Antiepileptics: Decreases in plasma concentrations of valproic acid to subtherapeutic levels have been noted in 2 patients during therapy with meropenem and amikacin. Meropenem was regarded as the likely cause of the interaction with valproic acid. Marked reductions in valproate concentrations have also been reported in 3 children given panipenem (with betamipron).
