Merovex 500/Merovex 1000

Merovex 500/Merovex 1000

meropenem

Manufacturer:

Venus Remedies

Distributor:

VE Pharma
Concise Prescribing Info
Contents
Meropenem trihydrate
Indications/Uses
Treatment of pneumonia including community-acquired & nosocomial pneumonia, bronchopulmonary infections in cystic fibrosis; complicated UTI & intra-abdominal, skin & soft tissue; intra- & postpartum infections, acute bacterial meningitis. Management of neutropenic patients w/ fever that is suspected to be due to a bacterial infection.
Dosage/Direction for Use
Nosocomial infection due to P. aeruginosa or Acinetobacter spp Adult & adolescent 500 mg or 1 g. Childn 10 mg or 20 mg/kg. Adult & adolescent Bronchopulmonary infections in cystic fibrosis, acute bacterial meningitis 2 g. Pneumonia including community-acquired & nosocomial pneumonia; complicated UTI & intra-abdominal, skin & soft tissue infection, intra- & postpartum infections 500 mg or 1 g. Management of febrile neutropenic patient 1 g. Childn 3 mth-11 yr & up to 50 kg Pneumonia including community-acquired & nosocomial pneumonia; complicated UTI & intra-abdominal, skin & soft tissue, intra- & postpartum infections 10 or 20 mg/kg. Bronchopulmonary infections in cystic fibrosis, acute bacterial meningitis 40 mg/kg. Management of febrile neutropenic patient 20 mg/kg. Childn >50 kg Adult dose, <3 mth 20 mg/kg. All doses to be given by IV infusion over approx 15-30 min, for every 8 hr.
Contraindications
Hypersensitivity. Severe hypersensitivity (eg, anaphylactic or skin reaction) to other type of β-lactam antibacterial agent (eg, penicillins or cephalosporins).
Special Precautions
History of or previous hypersensitivity to carbapenems, penicillins or other β-lactam antibiotics. Discontinue & appropriate measures be taken if severe allergic reaction occurs. Avoid concomitant use w/ probenecid & products that inhibits peristalsis. Consider diagnosis of antibiotic-associated colitis & pseudomembranous colitis in patients w/ diarrhea. Discontinue use & consider treatment for Clostridium difficile. Childn <3 mth.
Adverse Reactions
Headache, syncope, insomnia, agitation, delirium, confusion, fever, dizziness, pain, seizures, nervousness, paresthesia, hallucination, somnolence, anxiety, depression; heart failure, cardiac arrest, MI, pulmonary embolism, tachycardia, chest pain, HTN, bradycardia, hypotension; diarrhea, nausea, vomiting, constipation, abdominal pain or enlargement, oral candidiasis, anorexia; dysuria, kidney failure; bleeding events, anemia; hepatic failure, cholestatic jaundice, jaundice, flatulence, ileus; back pain; apnea, hypoxia, resp disorder, dyspnea; rash, pruritus, urticaria, sweating, inflammation, pain, edema, phlebitis or thrombophlebitis at inj site; hypersensitivity reactions, anaphylaxis, sepsis, shock, peripheral edema.
Drug Interactions
Inhibited renal excretion w/ probenecid. May decrease blood levels of valproic acid. May augment anticoagulant effects of warfarin.
MIMS Class
ATC Classification
J01DH02 - meropenem ; Belongs to the class of carbapenems. Used in the systemic treatment of infections.
Presentation/Packing
Form
Merovex 500 powd for inj 500 mg
Packing/Price
(+ 10 mL diluent ) 20 mL x 1's
Form
Merovex 1000 powd for inj 1000 mg
Packing/Price
(+ 20 mL diluent ) 20 mL x 1's
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