Merozan

Merozan

meropenem

Manufacturer:

Demo S. A.

Distributor:

PHARMASIA
Concise Prescribing Info
Contents
Meropenem trihydrate
Indications/Uses
Nosocomial pneumonias, pneumonias in immunosuppressed patients, pneumonias not responding to other antibacterial treatments. Intra-abdominal, gynecological (eg, endometritis & pelvic inflammatory), skin & soft tissues infections, UTI (complicated & non-complicated); meningitis, septicemia in adult & childn. Empiric treatment for presumed infections in adult patients w/ febrile neutropenia. Monotherapy or in combination w/ other antimicrobial agents for cystic fibrosis, chronic lower resp tract & polymicrobial infections
Dosage/Direction for Use
Adult Pneumonia, UTI, gynecological infections eg, endometritis, pelvic inflammatory disease, skin & skin structure infections 500 mg IV every 8 hr. Nosocomial pneumonias, peritonitis, presumed infections in neutropenic patient & septicemia 1 g IV every 8 hr. Meningitis & lung infections in patient w/ cystic fibrosis 2 g every 8 hr. Childn >50 kg Adult dose. Childn >3 mth & up to 12 yr 10-40 mg/kg every 8 hr. Meningitis & cystic fibrosis 40 mg/kg every 8 hr. Neutropenic patient w/ fever 20 mg/kg every 8 hr. Administered as IV bolus inj over approx 5 min or IV infusion over approx 15-30 min. Renal impairment w/ CrCl 26-50 mL/min 1 unit dose every 12 hr; 10-25 mL/min ½ unit dose every 12 hr; <10 mL/min ½ unit dose every 24 hr.
Contraindications
Hypersensitivity to meropenem, carbapenems, penicillins or other β-lactam antibiotics.
Special Precautions
Overgrowth of nonsusceptible organisms may occur. Not use for methicillin-resistant staphylococci infections. Consider diagnosis of pseudomembranous colitis in patients who develop diarrhea. Co-administration w/ potentially nephrotoxic drugs. Pregnancy & lactation. Not recommended in infant <3 mth.
Adverse Reactions
Inflammation, thrombophlebitis, pain at inj site; rash, pruritus, urticaria; abdominal pain, nausea, vomiting, diarrhea; thrombocythemia, eosinophilia, thrombocytopenia, leucopenia, neutropenia, +ve direct or indirect Coombs' test, reduction in partial thromboplastin time; increased serum bilirubin, transaminases, alkaline phosphatase & lactic dehydrogenase; headache, paresthesia; oral & vag candidiasis.
Drug Interactions
Increased elimination t½ & plasma conc w/ probenecid. May reduce serum levels of valproic acid.
MIMS Class
ATC Classification
J01DH02 - meropenem ; Belongs to the class of carbapenems. Used in the systemic treatment of infections.
Presentation/Packing
Form
Merozan powd for inj 1 g
Packing/Price
1's (P2,500/vial)
Form
Merozan powd for inj 500 mg
Packing/Price
1's (P1,500/vial)
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