Metampicillin


Concise Prescribing Info
Indications/Uses
Susceptible infections.
Dosage/Direction for Use
Adult : PO 1.5 g/day.
Dosage Details
Oral
Susceptible infections
Adult: 1.5 g/day. May also be given via parenteral routes.
Contraindications
Hypersensitivity to penicillins.
Special Precautions
Discontinue if skin rash occurs; risk increased in infectious mononucleosis, lymphatic leukaemia or possibly HIV-infected patients. Avoid large doses, especially in patients with renal impairment. Monitor renal, hepatic and haematological functions. Superinfection with penicillin-resistant organisms with prolonged use.
Adverse Reactions
Skin rash (urticarial or maculopapular), diarrhoea, nausea, vomiting, pseudomembranous colitis.
Potentially Fatal: Anaphylaxis.
Drug Interactions
Antagonism with rifampicin (high penicillin concentration) or synergism with rifampicin (low penicillin concentration). May reduce serum concentration of sulfapyridine (metabolite of sulfasalazine). May decrease renal clearance of methotrexate. May reduce efficacy of oral contraceptives. Increased serum concentrations with probenecid. Increased risk of rash with allopurinol.
Lab Interference
May interfere with tests for urinary glucose using copper sulfate, direct Coombs' test, and certain tests for urinary or serum proteins. May interfere with tests that use bacteria.
Action
Description: Metampicillin, like other penicillins, exerts its bactericidal action by inhibiting bacterial cell wall synthesis. It has the same antibacterial spectrum as ampicillin.
Pharmacokinetics:
Distribution: Distributes in CSF.
Metabolism: Oral dose completely hydrolysed to ampicillin.
Excretion: High biliary excretion (IV).
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Metampicillin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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