Each Film-Coated tablet contains: Metformin Hydrochloride 500 mg, or Metformin Hydrochloride 850 mg.
Pharmacology: Pharmacokinetics: Metformin Hydrochloride is slowly and incompletely absorbed from the gastro-intestinal tract. A single 500-mg dose is reported to have a bioavailability of 50-60% (may be reduced in the presence of food). Plasma protein binding is negligible. It is excreted as unchanged drug in the urine. Plasma elimination half-life is reported to range from about 2 to 6 hours after oral administration.
Metformin Hydrochloride is a biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus. It is given to patients who are no longer responding to sulphonylureas, either alone or in combination with sulphonylurea.
Adult: Initial dose is 500 mg two or three times daily or 850 mg once or twice daily, with or after meals, gradually increased if necessary to a maximum of 2 to 3 g daily. Or as prescribed by a physician.
Metformin Hydrochloride should not be used in insulin-dependent diabetes mellitus. Use in non-insulin-dependent diabetes mellitus is contraindicated in patients with ketoacidosis and in those with severe infection, stress, trauma and other severe conditions where it is unlikely to control hyperglycemia.
It should not be given in severe impairment of renal or hepatic function because of an increased risk of hypoglycemia.
It should not be given to pregnant or lactating women since it is excreted in breast milk.
It should not be used in patients with heart failure, recent myocardial infarction, dehydration, acute or chronic alcoholism or any other condition likely to predispose to lactic acidosis.
It should not be given to pregnant or lactating women since it is excreted in breast milk.
Metformin Hydrochloride causes gastro-intestinal adverse effects including anorexia, nausea and diarrhea; absorption of various substances including Vitamin B
12 may be impaired. Patients may experience metallic taste and there may be weight loss.
Reduction in Metformin Hydrochloride dosage may be required in patients receiving Metformin Hydrochloride and Cimetidine concomitantly to reduce the risk of lactic acidosis.
Store at temperatures not exceeding 30°C.
A10BA02 - metformin ; Belongs to the class of biguanides. Used in the treatment of diabetes.
FC tab 500 mg x 100's. 850 mg x 100's.
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