Metformin is contraindicated in patients with: Renal disease or renal dysfunction (e.g., as suggested by serum creatinine levels ≥ 1.5mg/dL (males), ≥1.4 mg/dL (females) or abnormal creatinine clearance) which may also result from conditions such as cardiovascular collapse shock), acute myocardial infarction, and septicemia.
Congestive heart failure requiring pharmacologic treatment.
Known hypersensitivity to metformin hydrochloride.
Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma. Diabetic ketoacidosis should be treated with insulin.
Metformin should be temporarily discontinued in patients undergoing radiologic studies involving intravascular administration iodinated contrast materials, because use of such products may result in acute alteration of renal function.