Methyltestosterone


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Male hypogonadism Androgen deficiency: 10-50 mg/day . Postpubertal cryptorchidism: 30 mg/day. Menopausal vasomotor symptoms unresponsive to estrogens alone 1.25-2.5 mg/day w/ estrogen for 21 days or 28-day cycle. Metastatic breast carcinoma in postmenopausal women 50-200 mg/day. Prevention of postpartum breast pain and engorgement 80 mg/day for 3-5 days after childbirth. Buccal Male hypogonadism Androgen deficiency: 5-25 mg/day. Postpubertal cryptorchidism: 15 mg/day. Metastatic breast carcinoma in postmenopausal women 25-100 mg/day. Prevention of postpartum breast pain and engorgement 40 mg/day for 3-5 days after childbirth.
Dosage Details
Buccal
Prophylaxis of postpartum breast pain and engorgement
Adult: 40 mg daily for 3-5 days after childbirth.

Buccal
Metastatic breast carcinoma in postmenopausal women
Adult: 25-100 daily.

Buccal
Male hypogonadism
Adult: Androgen deficiency: 5-25 mg daily. Postpubertal cryptorchidism: 15 mg daily.

Oral
Menopausal vasomotor symptoms
Adult: For short term treatment: 1.25-2.5 mg daily in combination with estrogen for 21 days or 28-day cycle.

Oral
Male hypogonadism
Adult: Androgen deficiency: 10-50 mg daily . Postpubertal cryptorchidism: 30 mg daily.

Oral
Metastatic breast carcinoma in postmenopausal women
Adult: 50-200 mg daily.

Oral
Prophylaxis of postpartum breast pain and engorgement
Adult: 80 mg daily for 3-5 days after childbirth.
Contraindications
In males, known or suspected carcinoma of the breast or prostate. Pregnancy. Severe hepatic impairment.
Special Precautions
Hepatic impairment; monitor liver function periodically. Breast cancer in women; may cause hypercalcaemia. DM. Conditions influenced by oedema (e.g. CV disease, migraine, seizure disorder, renal impairment). Elderly. May accelerate bone maturation without compensatory gain in linear growth in children. Monitor for signs of virilisation in women (discontinue if mild virilisation develops) and development of priapism or excessive sexual stimulation in men. Lactation.
Adverse Reactions
Oedema; headache, anxiety, depression; acne, male-pattern baldness, seborrhoea; hypercalcaemia, hypercholesterolaemia; GI irritation, nausea, vomiting; leucopenia, polycythemia; hypersensitivity reactions. Male: Virilism, priapism, prostatic hyperplasia, prostatic carcinoma, impotence, testicular atrophy, gynaecomastia. Female: Virilism, menstrual irregularities (amenorrhoea), breast soreness, hirsutism (increase in pubic hair growth), atrophy.
Potentially Fatal: Cholestatic hepatitis with jaundice, peliosis hepatis, hepatic neoplasms.
Overdosage
Abnormal LFTs.
Drug Interactions
May increase effects of oral anticoagulants and hypoglycaemic agents.
Potentially Fatal: May increase risk of ciclosporin toxicity.
Lab Interference
May decrease thyroxine-binding globulin concentrations.
Action
Description: Methyltestosterone is a synthetic androgenic anabolic steroid hormone. It promotes growth and development of male sex organs by stimulating receptors in organs and tissues, and maintains secondary sex characteristics in androgen-deficient men.
Pharmacokinetics:
Absorption: Absorbed from the GI tract and from the oral mucosa.
Metabolism: Hepatic.
Excretion: Via urine.
Disclaimer: This information is independently developed by MIMS based on Methyltestosterone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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