Metrogyl

Metrogyl Mechanism of Action

metronidazole

Manufacturer:

Unique Pharma Lab

Distributor:

Ambica

Marketer:

RiteMED
Full Prescribing Info
Action
Pharmacology: Pharmacokinetics: Topical administration of a one gram dose of Metronidazole (Metrogyl), to the face of 13 patients with moderate to severe rosacea once daily for 7 days resulted in a mean ± SD Cmax of metronidazole of 32 ± 9 ng/mL. The mean SD AUC(0-24) was 595 ± 154 ng*hr/mL. The mean Cmax and AUC(0-24) are less than 1% of the value reported for a single 250 mg oral dose of metronidazole. The time to maximum plasma concentration (Tmax) was 6-10 hours after topical application.
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