Micotran Drug Interactions





Full Prescribing Info
Drug Interactions
Drug interactions related to miconazole is less likely to occur during the use of Micotran, but it should be considered that the following interactions can be seen due to concomitant use with the following drugs:
Acenocoumarol, Anisindione, Dicumarol, Phenindione, Phenprocoumon, Warfarin: Increase in bleeding risk.
Astemizole, Cisaprid and Terfenadine: Metronidazole inhibits the metabolism of these drugs and increases the plasma concentrations.
Cyclosporine: Increase in cyclosporine risk (renal dysfunction, cholestasis, paresthesia).
Fentanyl: Increase or long taking effects of opioid (central nervous system depression, respiratory depression).
Phenytoin and Phosphenytoin: Increase in phenytoin toxicity risk (ataxia, hyperreflexia, nystagmus, tremor).
Glimepiride: Hypoglycemia.
Carbamazepine: Reduction in carbamazepine metabolism.
Oxybutinin: Due to inhibition of oxybutinin metabolism, exposure to oxybutinin and increase in plasma concentration (dry mouth, constipation, headache).
Oxycodone: Increase in oxycodone plasma concentration and reduction in clearance.
Pimozide: Increase in cardiotoxicity risk (QT prolongation, Torsades de pointes, cardiac arrest).
Tolterodine: Increase in tolterodine bioavalaibility in people with weak cyctochrome P450 2D6 activity.
Trimetrexate: Increase in trimetrexate toxicity (bone marrow suppression, renal and hepatic dysfunction and gastrointestinal ulceration).
Special Populations: Possibility of increase anticoagulant effect due to interact of absorbed Miconazole nitrate in low levels with warfarin and oral anticoagulants (acenocoumarol, dicumarol, phenindione).
No interaction study has been conducted in pediatric population.
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