Overdosage increases the risk of fluid retention and hyponatremia. Although the treatment of hyponatremia should be individualized, the following general recommendations can be given:
Asymptomatic hyponatremia is treated with discontinuation of desmopressin treatment and fluid restriction. Infusion of isotonic or hypertonic sodium chloride may be added in cases with symptoms. When the fluid retention is severe (convulsions and unconsciousness), treatment with furosemide should be added.