The principal adverse reactions associated with the administration of MMF include diarrhea, leukopenia, sepsis, vomiting and there is evidence of a higher frequency of certain types of infections. Serious life-threatening infections eg, meningitis and infectious endocarditis have been reported occasionally and there is evidence of a higher frequency of certain types of serious infections eg, tuberculosis and atypical mycobacterial infection.
Other adverse reactions reported in combination with cyclosporine and corticosteroids are as follows: Cardiovascular: Angina pectoris, atrial fibrillation, hypotension, palpitation, peripheral vascular disorder, postural hypotension, tachycardia, thrombosis, vasodilation, ventricular extrasystole, congestive heart failure (CHF), supraventricular tachycardia, ventricular tachycardia, atrial flutter, pulmonary hypertension, heart arrest, increased venous pressure, syncope, supraventricular extrasystoles, pallor, vasospasm.
Central Nervous System:
Anxiety, depression, hypertonia, paresthesia, somnolence, emotional lability, neuropathy, convulsion, hallucinations, abnormal thinking, vertigo.
Alopecia, fungal dermatitis, hirsutism, pruritus, benign skin neoplasm, skin disorder, sweating, hemorrhage, skin carcinoma.
Diabetes, parathyroid disorder, Cushing's syndrome and hypothyroidism.
Anorexia, esophagitis, flatulence, gastritis, gastroenteritis, gastrointestinal hemorrhage, gingivitis, gum hyperplasia, hepatitis, ileus, infection, mouth ulceration; rectal disorder, liver damage, dysphagia, jaundice, stomatitis, thirst.
Albuminuria, dysuria, hydronephrosis, impotence, pain, pyelonephritis, urinary frequency, nocturia, kidney failure, urine abnormality, hematuria, urinary incontinence, prostatic disorder, urinary retention.
: Arthralgia, joint disorder, leg cramps, myalgia, myasthenia.
Asthma, lung edema, pleural effusion, rhinitis, sinusitis, atelectasis, hiccups, pneumothorax, increased sputum, epistaxis, apnea, voice alteration, pain, hemoptysis, neoplasm, respiratory acidosis.
Amblyopia, cataract, conjunctivitis, ear pain, deafness, deafness, ear disorder, tinnitus, abnormal vision, lacrimation disorder, eye hemorrhage.
Enlarged abdomen, chills/fever, cyst, face edema, flu syndrome, hemorrhage, hernia, malaise, pelvic pain, ecchymosis, polycythemia, neck pain, cellulitis, increased prothrombin, decreased thromboplastin, petechia, phlebitis, thrombosis, weight gain/loss, abnormal healing dehydration.
Laboratory Test Abnormalities:
Increased alkaline phosphatase, creatinine, γ-glutamyl transpeptidase, lactic dehydrogenase, aspartate transaminase (AST) and alanine transaminase (ALT), hypercalcemia, hyperlipidemia, hyperuricemia, hypervolemia; hypocalcemia, hypoglycemia, hypoproteinemia, acidosis, hypoxia, hypophosphatemia, alkalosis, hypochloremia.