Motilia

Motilia

domperidone

Manufacturer:

2 World Lab

Distributor:

2 World Traders Subic
Concise Prescribing Info
Contents
Domperidone maleate
Indications/Uses
Dyspeptic symptom complex associated w/ delayed gastric emptying, GERD, esophagitis eg, epigastric sense of fullness, early satiety, feeling of abdominal distension, upper abdominal pain, bloating, eructation, flatulence, heartburn w/ or w/o regurgitation of gastric contents in the mouth. Nausea & vomiting of functional, organic, infectious or dietetic origin or induced by radio or drug therapy.
Dosage/Direction for Use
Nausea & vomiting 10-20 mg tid-qid. Max: 80 mg daily. Symptomatic management of non-ulcer dyspepsia 10 mg qid (last dose to be taken at night), may be increased to 20 mg if necessary. Max initial course of treatment: 2-4 wk. Migraine 20 mg. Max: 4 doses in 24 hr.
Administration
Should be taken on an empty stomach: Take 15-30 min before meals.
Contraindications
Hypersensitivity. Not to be used when GI stimulation is avoided & harmful eg, GI hemorrhage, obstruction or perforation. Patients w/ prolactin-releasing pituitary tumor (prolactinoma). Pregnancy & lactation.
Special Precautions
Not for chronic nausea & vomiting or for routine prophylaxis of post-op vomiting. Patients w/ hypokalemia. Avoid concomitant use w/ oral ketoconazole, erythromycin or other potent CYP3A4 inhibitors that prolong QT2 interval. Hepatic impairment, renal insufficiency. Neurotics, infants, toddler, childn. Elderly.
Adverse Reactions
Increased prolactin levels; GI disorders including very rare transient intestinal cramps; galactorrhea, gynecomastia, amenorrhea. Convulsion, agitation, somnolence.
Drug Interactions
Increased plasma levels w/ CYP3A4 inhibitors. Inhibition first-pass metabolism & increased in mean QTc w/ oral ketoconazole & erythromycin.
MIMS Class
GIT Regulators, Antiflatulents & Anti-Inflammatories / Antiemetics
ATC Classification
A03FA03 - domperidone ; Belongs to the class of propulsives. Used in the treatment of functional gastrointestinal disorders.
Presentation/Packing
Form
Motilia tab 10 mg
Packing/Price
10's
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