Skin rashes may occur during therapy with lamotrigine. Severe skin reactions including Stevens-Johnson syndrome were reported especially in children and usually occur within 8 weeks of starting lamotrigine.
Symptoms eg, fever, malaise, flu-like symptoms, drowsiness, lymphadenopathy, facial edema, and rarely, hepatic dysfunction, leukopenia and thrombocytopenia have also been reported with rashes as part of hypersensitivity syndrome.
Other adverse effects include angioedema and photosensitivity, diplopia, blurred vision and conjunctivitis and dizziness, drowsiness, insomnia, headache, ataxia, nystagmus, tremor, tiredness, nausea and vomiting, irritability and aggression, hallucinations, agitation and confusion. Very rarely, lupus-like reactions have been reported.