Naphazoline + Pheniramine

Ophthalmic
Ocular allergy

Angle closure glaucoma.

Glaucoma, hypertension, CV abnormalities, DM, hyperthyroidism, infection, or injury. Pregnancy and lactation. Avoid in infants and young children <6 yr. Rebound congestion may occur with prolonged use or overuse. Patient to seek medical advice if there is ocular pain, vision changes, worsening of redness or irritation of the eye or symptoms lasts >72 hr. Remove contact lens before use.

Blurring of vision, mild stinging and/or irritation, mydriasis and increased or decreased intraocular pressure. When used in high doses in elderly, naphazoline may liberate pigment granules from the iris.

Ophth: C

Increased pressor effects with maprotiline or TCA. Possibility of severe hypertensive reaction with MAOI.

Description: Naphazoline, an imidazoline derivative is a sympathomimetic with α-adrenergic activity. It produces vasoconstriction. When applied topically to mucous membranes, it reduces swelling and congestion. It is often used in combination with pheniramine, an alkylamine derivative antihistamine, in ophthalmic preparations.
Onset: Local vasoconstriction: Within 10 minutes
Duration: Local vasoconstriction: 2-6 hr

Other Eye Preparations